Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Ann Epidemiol. 2010 Jan;20(1):8-15. doi: 10.1016/j.annepidem.2009.09.009.
To examine the association between prepregnancy depressive symptoms and preterm birth.
The present study is a prospective investigation of prepregnancy depressive symptoms-measured by the Center for Epidemiologic Studies Depression Scale (CES-D)-and risk of preterm birth reported in the Black Women's Health Study. With data on 2,627 singleton births (175 spontaneous and 163 medically indicated preterm births and 2,289 term births), we used generalized estimating equation models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders.
Relative to mothers with CES-D scores less than 16, the multivariable ORs of spontaneous preterm birth for mothers with CES-D scores of 16-22, 23-32, and > or =33 were 1.17 (95% CI = 0.78-1.80), 1.20 (95% CI = 0.69-2.10), and 2.00 (95% CI = 0.94-4.25), respectively (p for trend = 0.09). There was little evidence of an association between prepregnancy depressive symptoms and medically indicated preterm birth.
Our data provide some evidence of an increased risk of spontaneous preterm birth among women with high prepregnancy depressive symptoms.
探讨孕前抑郁症状与早产的关系。
本研究是对 Black Women's Health Study 中孕前抑郁症状（采用流行病学研究中心抑郁量表（CES-D）测量）与早产风险的前瞻性研究。共有 2627 例单胎分娩（175 例自发性早产和 163 例医学指征性早产，2289 例足月产），采用广义估计方程模型，调整潜在混杂因素后，估计比值比（OR）和 95%置信区间（CI）。
与 CES-D 评分<16 的母亲相比，CES-D 评分 16-22、23-32 和≥33 的母亲自发性早产的多变量 OR 分别为 1.17（95%CI：0.78-1.80）、1.20（95%CI：0.69-2.10）和 2.00（95%CI：0.94-4.25）（趋势检验 p=0.09）。孕前抑郁症状与医学指征性早产之间几乎没有关联。
我们的数据提供了一些证据表明，孕前抑郁症状严重的女性自发性早产风险增加。
