Department of Surgery, University of Virginia, Charlottesville, VA, USA.
J Thorac Cardiovasc Surg. 2010 Feb;139(2):263-72. doi: 10.1016/j.jtcvs.2009.09.006. Epub 2009 Dec 16.
Increasingly, patients with previous sternotomy require aortic valve replacement. We compared outcomes of reoperative aortic valve replacement after previous sternotomy and primary aortic valve replacement by surgical era. Effect of initial cardiac operation on reoperative aortic valve replacement was also investigated.
Between January 1996 and December 2007, a total of 1603 patients undergoing elective aortic valve replacement were entered prospectively into our clinical database. Patients were divided into eras A (1996-1999), B (2000-2003), and C (2004-2007). A total of 191 patients (12%) had previous sternotomy for coronary artery bypass grafting (n = 88), coronary artery bypass grafting with aortic valve replacement (n = 16), aortic valve replacement with or without other aortic procedure (n = 70), and other cardiac procedures (n = 17). Mean ages were 66.5 +/- 13.1 years in reoperative group and 65.5 +/- 14.9 years in primary group.
Mortality in reoperative group decreased significantly with time (A 15.4% vs B 15.1% vs C 2.0%, P = .004) and was equivalent to primary group in era C (3.5% vs 2.0%, P = .65). Major complications also significantly decreased with time in reoperative group (A 25.6% vs B 17.0% vs C 6.1%, P = .006). Importantly, patients had more comorbidities with time and increased preoperative risk in era C. There were no differences in outcome by initial cardiac operation in reoperative group.
Reoperative aortic valve replacement now carries similar morbidity and mortality to primary replacement. Risk of reoperation is not affected by primary operation.
越来越多先前接受过胸骨切开术的患者需要进行主动脉瓣置换。我们比较了不同外科时代下,先前胸骨切开术后再次行主动脉瓣置换的手术结果。此外,我们还研究了初始心脏手术对再次行主动脉瓣置换术的影响。
1996 年 1 月至 2007 年 12 月,共有 1603 例行择期主动脉瓣置换术的患者前瞻性纳入我们的临床数据库。患者被分为 A 时代(1996-1999 年)、B 时代(2000-2003 年)和 C 时代(2004-2007 年)。共有 191 例(12%)患者先前因冠状动脉旁路移植术(n=88)、冠状动脉旁路移植术联合主动脉瓣置换术(n=16)、单纯主动脉瓣置换术或联合其他主动脉手术(n=70)或其他心脏手术(n=17)而行胸骨切开术。再次手术组的平均年龄为 66.5±13.1 岁,初次手术组的平均年龄为 65.5±14.9 岁。
再次手术组的死亡率随时间推移显著降低(A 时代 15.4%,B 时代 15.1%,C 时代 2.0%,P=.004),与 C 时代的初次手术组(3.5% vs 2.0%,P=.65)相当。再次手术组的主要并发症也随时间推移显著减少(A 时代 25.6%,B 时代 17.0%,C 时代 6.1%,P=.006)。重要的是,随着时间的推移,患者的合并症增多,C 时代的术前风险增加。再次手术组中,初始心脏手术对手术结果无影响。
目前,再次行主动脉瓣置换术的发病率和死亡率与初次置换术相似。再次手术的风险不受初次手术的影响。