Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan, ROC.
Metabolism. 2010 Jun;59(6):848-53. doi: 10.1016/j.metabol.2009.10.001. Epub 2009 Dec 16.
A growing body of evidence strongly supports associations between reduced lung function and insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. The present study was undertaken to explore the possibility that reduced lung function is an independent predictor of development of the metabolic syndrome (MetS) and to investigate potential links between reduced lung function and the MetS. A prospective cohort study of reduced lung function as a predictor of subsequent MetS was conducted using 2-year follow-up data for 450 middle-aged adults lacking the MetS at baseline. Data were obtained from the Taipei MJ Health Screening Centers in Taiwan. The MetS was defined according to the modified Adult Treatment Panel III criteria. Over 2 years of follow-up, 26 of the 450 subjects (5.78%) without the MetS at baseline subsequently developed the syndrome. In multiple logistic regression analysis with adjustments for age, sex, body mass index, cigarette smoking, alcohol consumption, and physical activities, reduced forced expiratory volume in the first second (FEV(1)) at baseline remained a predictor of subsequent MetS (relative risk of 4.644, P = .036 for the third [<2.31 L] vs first [>2.88 L] tertile). In Pearson and partial correlation analyses, white blood cell counts and C-reactive protein concentrations were both found to be significantly and negatively correlated with FEV(1). Lower FEV(1) is concluded to serve as an independent predictor of the MetS. Low-grade systemic inflammation is the possible link between reduced lung function and the MetS.
越来越多的证据强烈支持肺功能降低与胰岛素抵抗、2 型糖尿病和心血管疾病之间的关联。本研究旨在探讨肺功能降低是否是代谢综合征（MetS）发展的独立预测因素，并研究肺功能降低与 MetS 之间的潜在联系。采用前瞻性队列研究，使用 450 名中年成年人的 2 年随访数据，这些成年人在基线时没有 MetS，研究肺功能降低作为随后发生 MetS 的预测指标。数据来自台湾台北市的 Mj 健康筛查中心。MetS 根据改良成人治疗小组 III 标准定义。在基线时没有 MetS 的 450 名受试者中，有 26 名（5.78%）在 2 年的随访中随后出现了该综合征。在多变量逻辑回归分析中，调整年龄、性别、体重指数、吸烟、饮酒和体力活动后，基线时的用力呼气量第一秒（FEV1）降低仍然是随后发生 MetS 的预测因素（相对风险为 4.644，P =.036，第三 [<2.31 L] 与第一 [>2.88 L] 三分位）。在 Pearson 和偏相关分析中，白细胞计数和 C 反应蛋白浓度均与 FEV1 呈显著负相关。FEV1 降低被认为是 MetS 的独立预测因素。低度全身炎症可能是肺功能降低与 MetS 之间的联系。
