Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA.
Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY 11201, USA.
Int J Environ Res Public Health. 2020 Sep 9;17(18):6569. doi: 10.3390/ijerph17186569.
Fire Department of New York (FDNY) rescue and recovery workers exposed to World Trade Center (WTC) particulates suffered loss of forced expiratory volume in 1 s (FEV). Metabolic Syndrome increased the risk of developing WTC-lung injury (WTC-LI) We aim to attenuate the deleterious effects of WTC exposure through a dietary intervention targeting these clinically relevant disease modifiers. We hypothesize that a calorie-restricted Mediterranean dietary intervention will improve metabolic risk, subclinical indicators of cardiopulmonary disease, quality of life, and lung function in firefighters with WTC-LI. To assess our hypothesis, we developed the Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE), a randomized controlled clinical trial (RCT). Male firefighters with WTC-LI and a BMI > 27 kg/m will be included. We will randomize subjects (1:1) to either: (1) Low Calorie Mediterranean (LoCalMed)-an integrative multifactorial, technology-supported approach focused on behavioral modification, nutritional education that will include a self-monitored diet with feedback, physical activity recommendations, and social cognitive theory-based group counseling sessions; or (2) Usual Care. Outcomes include reduction in body mass index (BMI) (primary), improvement in FEV, fractional exhaled nitric oxide, pulse wave velocity, lipid profiles, targeted metabolic/clinical biomarkers, and quality of life measures (secondary). By implementing a technology-supported LoCalMed diet our FIREHOUSE RCT may help further the treatment of WTC associated pulmonary disease.
纽约消防局（FDNY）的救援和恢复工作人员接触世界贸易中心（WTC）颗粒后，用力呼气 1 秒量（FEV）减少。代谢综合征增加了患 WTC 肺损伤（WTC-LI）的风险。我们旨在通过针对这些临床相关疾病修饰物的饮食干预来减轻 WTC 暴露的有害影响。我们假设，限制卡路里的地中海饮食干预将改善患有 WTC-LI 的消防员的代谢风险、心肺疾病的亚临床指标、生活质量和肺功能。为了评估我们的假设，我们开发了针对健康结果支持和教育的饮食摄入限制（FIREHOUSE），这是一项随机对照临床试验（RCT）。将纳入患有 WTC-LI 和 BMI>27kg/m 的男性消防员。我们将随机分配受试者（1:1）到以下两种方案之一：（1）低卡路里地中海饮食（LoCalMed）-一种综合的多因素、技术支持的方法，侧重于行为改变、营养教育，包括自我监测饮食和反馈、体力活动建议以及基于社会认知理论的小组咨询课程；或（2）常规护理。结果包括体重指数（BMI）降低（主要）、FEV、呼气一氧化氮分数、脉搏波速度、血脂谱、靶向代谢/临床生物标志物和生活质量测量的改善（次要）。通过实施基于技术的 LoCalMed 饮食，我们的 FIREHOUSE RCT 可能有助于进一步治疗与 WTC 相关的肺部疾病。
