Kim Chi Young, Park Youngmok, Leem Ah Young, Chung Kyung Soo, Jung Ji Ye, Park Moo Suk, Kim Young Sam
Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea,
Int J Chron Obstruct Pulmon Dis. 2018 Jun 28;13:2057-2063. doi: 10.2147/COPD.S157453. eCollection 2018.
Although studies have examined the relationship between metabolic syndrome (MetS) and COPD, the incidence of MetS in individuals with COPD has not specifically been investigated. This study aimed to evaluate the incidence of MetS in subjects with airway obstruction using data from a community-based cohort.
Data representing 4 years of follow-up from the Ansung-Ansan cohort were analyzed; a total of 6,184 adults, who were ≥40 years of age and underwent spirometry, were enrolled in this study. Airway obstruction was defined as forced expiratory volume in 1 s/forced vital capacity ratio <70%, and MetS was determined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines.
A total of 419 patients were newly diagnosed with MetS, based on the National Cholesterol Education Program Adult Treatment Panel III guidelines, during follow-up. MetS was more frequent in COPD subjects, relative to non-COPD subjects, in both sexes (14.7% vs 11.0% [men] and 14.7% vs 11.8% [women]). In men subjects, the risk for MetS was higher in subjects with airflow obstruction than in subjects without obstruction, after adjusting for age, body mass index, and smoking status.
The incidence of MetS was higher in men with airflow obstruction than in healthy subjects.
尽管已有研究探讨了代谢综合征（MetS）与慢性阻塞性肺疾病（COPD）之间的关系，但尚未专门研究COPD患者中MetS的发病率。本研究旨在利用基于社区队列的数据评估气道阻塞患者中MetS的发病率。
分析了安城-安山队列4年随访的数据；本研究共纳入了6184名年龄≥40岁且接受过肺活量测定的成年人。气道阻塞定义为1秒用力呼气容积/用力肺活量比值<70%，并根据美国国家胆固醇教育计划成人治疗小组第三次报告指南确定MetS。
根据美国国家胆固醇教育计划成人治疗小组第三次报告指南，在随访期间共有419例患者新诊断为MetS。在男性和女性中，COPD患者的MetS发生率均高于非COPD患者（男性：14.7%对11.0%；女性：14.7%对11.8%）。在男性受试者中，调整年龄、体重指数和吸烟状况后，气流阻塞患者发生MetS的风险高于无气流阻塞的患者。
气流阻塞男性患者中MetS的发病率高于健康受试者。
