Hein H O, Suadicani P, Gyntelberg F
Rigshospitalet, København, arbejdsmedicinsk klinik.
Ugeskr Laeger. 1991 Feb 11;153(7):493-6.
In The Copenhagen Male Study, an epidemiological study comprising 3,387 men aged 53 to 75 years, 3,303 men with valid questionnaire answers to questions on occupational organic solvents exposure, four cerebral symptoms and current work status were examined. Two hundred and ninety-five men had been occupationally exposed to mixed organic solvents for a period of five years or more. Among the exposed persons, 178 had retired, while 117 were still gainfully employed. The exposed men in both groups had highly significantly more complaints of decreased concentration and defective memory. Among the exposed retired men a higher prevalence of headache was found. Among the exposed men who were still employed a trend towards a higher prevalence of vertigo was found. This study was conducted within a cardiovascular study with no focus on the relationship between organic solvent exposure and cerebral symptoms, a design reducing the risk of overreporting. If overreporting was responsible for the differences found between solvent exposed and unexposed a similar pattern for reporting of acute and chronic symptoms should be expected. This was not the case. Our results support the hypothesis, that occupational exposure to organic solvents for a period of five years or more increases the risk of developing persistent defective memory and decrease in concentration.
在哥本哈根男性研究中，这是一项涵盖3387名年龄在53至75岁男性的流行病学研究，对3303名就职业有机溶剂暴露、四种脑部症状及当前工作状态问题给出有效问卷回答的男性进行了检查。295名男性曾在职业上接触混合有机溶剂达五年或更长时间。在这些接触者中，178人已退休，而117人仍在从事有报酬的工作。两组中的接触男性在注意力下降和记忆力缺陷方面的抱怨明显更多。在接触的退休男性中，头痛的患病率更高。在仍在工作的接触男性中，发现眩晕患病率有升高趋势。这项研究是在一项心血管研究中进行的，未聚焦于有机溶剂暴露与脑部症状之间的关系，这种设计降低了过度报告的风险。如果过度报告是导致接触溶剂者与未接触者之间差异的原因，那么急性和慢性症状的报告模式应该相似。但实际并非如此。我们的结果支持这一假设，即职业性接触有机溶剂达五年或更长时间会增加出现持续性记忆力缺陷和注意力下降的风险。
