Department of Psychology, University of York, Heslington, York YO10 5DD, UK.
Neuropsychologia. 2010 Mar;48(4):1089-95. doi: 10.1016/j.neuropsychologia.2009.12.009. Epub 2009 Dec 16.
A series of experiments test the recent claim that the hippocampus is necessary for the binding of features in working memory. Some potential limitations of studies underlying this claim are discussed, and an attempt is made to further test the hypothesis by studying a case of developmental amnesia whose extensively investigated pathology appears to be principally limited to the hippocampus, and who shows the expected deficit in episodic long-term memory. One series of experiments studied the short-term visual binding of color and shape under conditions ranging from simple presentation of colored objects through the more demanding task of combining the features when separated in space, or in time. A second set of experiments studied the capacity to use sentence structure to bind words into chunks in short-term verbal memory. Hippocampal pathology did not lead to a decrement on any of these tasks, suggesting that the hippocampus is not essential for short-term binding in working memory.
一系列实验检验了最近提出的海马体对于工作记忆中特征绑定是必需的这一说法。讨论了该说法所依据的研究的一些潜在局限性，并尝试通过研究一个发展性遗忘症的病例来进一步检验该假说，该病例的广泛研究的病理学似乎主要局限于海马体，并且在情景性长时记忆中表现出预期的缺陷。一系列实验研究了在从简单呈现彩色物体到更具挑战性的任务（例如在空间或时间上分离特征时组合特征）下，短期视觉颜色和形状的绑定。第二组实验研究了使用句子结构将单词绑定到短期言语记忆中的块的能力。海马体病理学并没有导致这些任务中的任何一个任务的下降，这表明海马体对于工作记忆中的短期绑定不是必需的。
