Department of Pharmacology and Neuroscience Program, Tulane University Medical School, New Orleans, LA 70112, USA.
Behav Brain Res. 2010 Apr 2;208(2):371-6. doi: 10.1016/j.bbr.2009.12.004. Epub 2009 Dec 16.
The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans and rodents, characterized by increased anxiety. Sensitivity of zebrafish to drugs of abuse has been recently reported in the literature. Here we examine the effects of ethanol, diazepam, morphine and caffeine withdrawal on zebrafish behavior. Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome.
斑马鱼（Danio rerio）迅速成为行为神经科学研究中的一种流行模式生物。斑马鱼的行为受到环境和药理学处理的强烈影响，可以使用基于探索的范式进行检查，同时分析内分泌（皮质醇）应激反应。人类和啮齿动物停止使用各种精神药物会引起戒断，表现出焦虑增加。最近的文献报道了斑马鱼对滥用药物的敏感性。在这里，我们检查了乙醇、地西泮、吗啡和咖啡因戒断对斑马鱼行为的影响。总的来说，乙醇、地西泮和吗啡的停用产生了类焦虑样行为或内分泌反应，证明了斑马鱼在戒断综合征的转化研究中的实用性。
