Jia CuiCui, Han Tong, Xu Jun, Li ShengGe, Sun YaTing, Li DaHong, Li ZhanLin, Hua HuiMing
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
J Nat Med. 2017 Oct;71(4):642-649. doi: 10.1007/s11418-017-1092-7. Epub 2017 May 26.
A new biflavonoid, paucinervin K (1) and a new triterpene, 23-hydroxy-friedelin (2), together with eleven known compounds 3-13 were isolated from the leaves of Garcinia paucinervis. Their structures, including stereochemistry, were determined by spectroscopic analysis of NMR, MS, IR and ECD calculation and the octant rule. Some of the isolated compounds were tested for antiproliferative, α-glucosidase inhibitory and antioxidant activities in vitro. Compounds 1, 3, 4, 5 and 9 showed moderate preferential antioxidant and hypoglycemic activities. Compounds 3-6 and 9 exhibited potent growth inhibition against HepG-2 and PC-3 cell lines with IC values ranging from 1.02-10.05 μM.
从少脉藤黄的叶子中分离出一种新的双黄酮类化合物——少脉藤黄素K（1）和一种新的三萜类化合物——23-羟基木栓酮（2），以及11种已知化合物3 - 13。通过核磁共振（NMR）、质谱（MS）、红外光谱（IR）的光谱分析、电子圆二色光谱（ECD）计算和八区规则确定了它们的结构，包括立体化学结构。对部分分离得到的化合物进行了体外抗增殖、α-葡萄糖苷酶抑制和抗氧化活性测试。化合物1、3、4、5和9表现出适度的优先抗氧化和降血糖活性。化合物3 - 6和9对HepG - 2和PC - 3细胞系表现出较强的生长抑制作用，IC值范围为1.02 - 10.05 μM。
