用于检测眼球震颤患者黄斑形态的光谱域光学相干断层扫描技术
Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus.
作者信息
Cronin Tara H, Hertle Richard W, Ishikawa Hiroshi, Schuman Joel S
机构信息
The UPMC and Children's Hospital Of Pittsburgh Eye Centers and The Laboratory of Visual and Ocular Motor Physiology Pittsburgh, PA 15201, USA.
出版信息
J AAPOS. 2009 Dec;13(6):563-6. doi: 10.1016/j.jaapos.2009.09.019.
PURPOSE
To evaluate the feasibility of spectral domain optical coherence tomography (SD-OCT) macular scanning as a means of studying the afferent visual system in nystagmus patients.
METHODS
Nystagmus patients who underwent SD-OCT, clinical evaluation, and eye movement recordings were recruited for this prospective, single-center, noncomparative study. Three SD-OCT macular three-dimensional cube scans per eye (200 x 200 x 1024 samplings in a 6 x 6 mm region) were obtained for qualitative retinal morphology analysis.
RESULTS
Nineteen patients (6-68 years; average, 19 years) were analyzed. Of these, 17 patients had infantile nystagmus syndrome, and 2 had fusion maldevelopment nystagmus; 17 patients (89%) had associated sensory system abnormalities, including 9 (47%) with albinism. Macular images were successfully obtained in all but 1 patient (95%). Of the 8 successfully imaged oculocutaneous patients, 7 patients demonstrated "fovea plana," and all demonstrated abnormal morphology.
CONCLUSION
SD-OCT reliably provides detailed structural imaging of the fovea in nystagmus patients.
目的
评估频域光学相干断层扫描（SD-OCT）黄斑扫描作为研究眼球震颤患者传入视觉系统方法的可行性。
方法
招募接受SD-OCT、临床评估和眼动记录的眼球震颤患者进行这项前瞻性、单中心、非对照研究。每只眼睛获取三次SD-OCT黄斑三维立方体扫描（在6×6毫米区域内进行200×200×1024次采样），用于定性视网膜形态分析。
结果
分析了19例患者（年龄6 - 68岁；平均19岁）。其中，17例患有婴儿型眼球震颤综合征，2例患有融合发育不良性眼球震颤；17例患者（89%）伴有感觉系统异常，包括9例（47%）患有白化病。除1例患者外，所有患者（95%）均成功获得黄斑图像。在8例成功成像的眼皮肤白化病患者中，7例表现为“扁平中央凹”，且均显示形态异常。
结论
SD-OCT能够可靠地提供眼球震颤患者黄斑的详细结构成像。
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