Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille 13288, France.
Cell Host Microbe. 2009 Dec 17;6(6):493-5. doi: 10.1016/j.chom.2009.12.001.
Natural Killer (NK) cells boost immune defense via their cytolytic activity and their capacity to produce interferon-gamma. Now Perona-Wright et al. (2009), in this issue of Cell Host & Microbe, show that NK cells can also dampen immune responses to diverse pathogens via secretion of the anti-inflammatory cytokine interleukin-10. Remarkably, this immunosuppressive activity only occurs during systemic infections.
自然杀伤 (NK) 细胞通过其细胞溶解活性和产生干扰素-γ的能力来增强免疫防御。现在，Perona-Wright 等人（2009）在本期《细胞宿主与微生物》中表明，NK 细胞还可以通过分泌抗炎细胞因子白细胞介素-10 来抑制对多种病原体的免疫反应。值得注意的是，这种免疫抑制活性仅在全身感染期间发生。
