脑谷氨酸的区域特异性改变：与冒险行为的可能关系。
Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior.
机构信息
Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
出版信息
Physiol Behav. 2010 Mar 30;99(4):445-50. doi: 10.1016/j.physbeh.2009.12.005. Epub 2009 Dec 13.
Abstract
Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed.
摘要
冒险行为涉及人类活动增加和焦虑减少。动物的总睡眠剥夺（SD）会导致运动和恐惧行为发生类似的变化。研究人员研究了 TSD 后大鼠特定区域脑内谷氨酸水平，TSD 是一种冒险行为的动物模型。我们研究了睡眠剥夺对这些行为和相关脑谷氨酸水平的影响。与对照组相比，睡眠剥夺的大鼠在高架十字迷宫（EPM）的开放臂中花费的时间明显更长，表明恐惧样行为减少，冒险行为增加。此外，睡眠剥夺与海马体和丘脑内谷氨酸水平的显著增加有关。内侧前额叶皮质中的谷氨酸与 EPM 中的冒险行为呈负相关，而海马体与内侧前额叶皮质的谷氨酸比值与冒险行为呈正相关。讨论了睡眠剥夺引起的脑谷氨酸变化及其与焦虑、恐惧和创伤后应激障碍（PTSD）的关系。
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