Department of Obstetrics and Gynaecology, Islamic Hospital, Amman, Jordan.
Maturitas. 2009 Dec;65 Suppl 1:S43-6. doi: 10.1016/j.maturitas.2009.11.013. Epub 2009 Dec 14.
The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage.
146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). Dydrogesterone was continued until 1 week after the bleeding had stopped. All women received standard supportive care.
The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p<0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities.
Dydrogesterone appears to have beneficial effects in women with threatened miscarriage.
本研究旨在确定地屈孕酮是否有助于预防有流产先兆的孕妇流产。
146 名在妊娠早期出现轻微或中度阴道出血的孕妇被随机分为两组，分别接受口服地屈孕酮（10mg，bid）（n=86）或不治疗（n=60）。地屈孕酮一直用到出血停止后一周。所有妇女均接受标准的支持性治疗。
地屈孕酮组的流产发生率明显低于未治疗组（17.5%比 25%；p<0.05）。两组在妊娠并发症或先天性异常方面无统计学差异。
地屈孕酮似乎对有流产先兆的孕妇有有益的作用。
