炎性小体相关核苷酸结合域、富含亮氨酸重复序列蛋白与炎症性疾病。
Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases.
机构信息
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
J Immunol. 2009 Dec 15;183(12):7623-9. doi: 10.4049/jimmunol.0902425.
Abstract
The nucleotide-binding domain, leucine-rich repeat (NLR) proteins are a recently discovered family of intracellular pathogen and danger signal sensors. NLRs have emerged as important contributors to innate immunity in animals. The physiological impact of these genes is increasingly evident, underscored by the genetic association of variant family members with an array of inflammatory diseases. The association of mutations in NLR genes with autoinflammatory diseases indicates an important function of these genes in inflammation in vivo. This review summarizes the role of the inflammasome NLR proteins in innate immunity and inflammatory diseases and explores the possible utility of some of these NLRs as pharmacological targets.
摘要
核苷酸结合域富含亮氨酸重复（NLR）蛋白是最近发现的一类细胞内病原体和危险信号传感器。NLR 已成为动物固有免疫的重要贡献者。这些基因的生理影响越来越明显，其家族成员的变体与一系列炎症性疾病的遗传关联强调了这一点。NLR 基因的突变与自身炎症性疾病的关联表明这些基因在体内炎症中具有重要功能。这篇综述总结了炎性小体 NLR 蛋白在先天免疫和炎症性疾病中的作用，并探讨了其中一些 NLR 作为药理学靶点的可能用途。
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