Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, USA.
J Appl Physiol (1985). 2010 Feb;108(2):334-42. doi: 10.1152/japplphysiol.01083.2009. Epub 2009 Dec 10.
Poor glycemic control in Type 1 diabetes (T1DM) causes long-term cardiovascular complications, at least in part via chronic, low-grade inflammation associated with recurrent hyperglycemia. While physical activity can reduce both inflammation and cardiovascular risks, the underlying molecular mechanisms remain unclear. This is particularly important for T1DM children, for whom the prevention of long-term cardiovascular complications must include optimization of exercise-related anti-inflammatory strategies. We therefore studied the effect of prior hyperglycemia on resting and exercise-induced inflammatory status (plasma IL-6) in T1DM children. Glycemia was continuously recorded with a continuous glucose monitoring system (CGMS) system for 63 h preceding a 30-min intermittent cycling exercise protocol at approximately 80% peak rate of oxygen uptake (VO2max). Euglycemia (4.4-6.1 mM) was maintained for 90 min before, during, and 30 min after exercise. IL-6 plasma concentration (pg/ml) was measured at baseline, at end exercise, and 30 min postexercise. Subjects were then divided into quartiles based on average glycemia during the CGMS recording. IL-6 levels (pg/ml) were lowest in the quartile with lowest average 3-day glycemia and increased proportionally to greater hyperglycemic exposure; this was observed at baseline (0.86 +/- 0.10, 1.06 +/- 0.16, 1.14 +/- 0.14, 1.20 +/- 0.16), absolute IL-6 change (Delta) at end exercise (0.20 +/- 0.16, 0.32 +/- 0.10, 0.48 +/- 0.09, 0.62 +/- 0.13), and Delta at 30 min postexercise (0.49 +/- 0.13, 0.71 +/- 0.16, 0.89 +/- 0.14, 1.38 +/- 0.33). Therefore, poorly controlled glycemic profile, even in the 63 h preceding an exercise challenge, can alter inflammatory adaptation in T1DM children. Our data underscore the necessity to fully understand all molecular aspects of physical activity to provide the scientific rationale for exercise regimens that will be able to maximize health benefits for T1DM children.
1 型糖尿病（T1DM）患者血糖控制不佳会导致长期心血管并发症，这至少部分是由于与反复高血糖相关的慢性低度炎症。虽然身体活动可以降低炎症和心血管风险，但潜在的分子机制尚不清楚。这对于 T1DM 儿童尤为重要，因为要预防长期心血管并发症，必须优化与运动相关的抗炎策略。因此，我们研究了先前高血糖对 T1DM 儿童静息和运动诱导炎症状态（血浆 IL-6）的影响。使用连续血糖监测系统（CGMS）连续记录血糖 63 小时，然后进行 30 分钟间歇性自行车运动试验，运动强度约为峰值摄氧量（VO2max）的 80%。在运动前、运动中和运动后 30 分钟内，将血糖维持在 4.4-6.1mM 之间。在基线、运动结束时和运动后 30 分钟测量血浆 IL-6 浓度（pg/ml）。然后根据 CGMS 记录期间的平均血糖将受试者分为四组。IL-6 水平（pg/ml）在平均 3 天血糖最低的四分位数中最低，并随着高血糖暴露的增加而成比例增加；这在基线（0.86 +/- 0.10、1.06 +/- 0.16、1.14 +/- 0.14、1.20 +/- 0.16）、运动结束时的绝对 IL-6 变化（Delta）（0.20 +/- 0.16、0.32 +/- 0.10、0.48 +/- 0.09、0.62 +/- 0.13）和运动后 30 分钟时的 Delta（0.49 +/- 0.13、0.71 +/- 0.16、0.89 +/- 0.14、1.38 +/- 0.33）中观察到。因此，即使在运动挑战前 63 小时，血糖控制不佳的情况也会改变 T1DM 儿童的炎症适应能力。我们的数据强调了充分了解身体活动的所有分子方面的必要性，以便为 T1DM 儿童提供能够最大程度地提高健康益处的运动方案的科学依据。
