Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
PLoS One. 2013;8(3):e57733. doi: 10.1371/journal.pone.0057733. Epub 2013 Mar 11.
To evaluate the effects of aerobic (AER) or aerobic plus resistance exercise (COMB) sessions on glucose levels and glucose variability in patients with type 2 diabetes. Additionally, we assessed conventional and non-conventional methods to analyze glucose variability derived from multiple measurements performed with continuous glucose monitoring system (CGMS).
Fourteen patients with type 2 diabetes (56±2 years) wore a CGMS during 3 days. Participants randomly performed AER and COMB sessions, both in the morning (24 h after CGMS placement), and at least 7 days apart. Glucose variability was evaluated by glucose standard deviation, glucose variance, mean amplitude of glycemic excursions (MAGE), and glucose coefficient of variation (conventional methods) as well as by spectral and symbolic analysis (non-conventional methods).
Baseline fasting glycemia was 139±05 mg/dL and HbA1c 7.9±0.7%. Glucose levels decreased immediately after AER and COMB protocols by ∼16%, which was sustained for approximately 3 hours. Comparing the two exercise modalities, responses over a 24-h period after the sessions were similar for glucose levels, glucose variance and glucose coefficient of variation. In the symbolic analysis, increases in 0 V pattern (COMB, 67.0±7.1 vs. 76.0±6.3, P = 0.003) and decreases in 1 V pattern (COMB, 29.1±5.3 vs. 21.5±5.1, P = 0.004) were observed only after the COMB session.
Both AER and COMB exercise modalities reduce glucose levels similarly for a short period of time. The use of non-conventional analysis indicates reduction of glucose variability after a single session of combined exercises.
Aerobic training, aerobic-resistance training and glucose profile (CGMS) in type 2 diabetes (CGMS exercise). ClinicalTrials.gov ID: NCT00887094.
评估有氧运动（AER）或有氧结合抗阻运动（COMB）对 2 型糖尿病患者血糖水平和血糖变异性的影响。此外，我们评估了常规和非常规方法，以分析来自连续血糖监测系统（CGMS）多次测量的血糖变异性。
14 名 2 型糖尿病患者（56±2 岁）在 3 天内佩戴 CGMS。参与者随机进行 AER 和 COMB 运动，均在 CGMS 放置后 24 小时（早上）进行，至少相隔 7 天。血糖变异性通过血糖标准差、血糖方差、血糖波动幅度（MAGE）和血糖变异系数（常规方法）以及谱和符号分析（非常规方法）进行评估。
基线空腹血糖为 139±05mg/dL，HbA1c 为 7.9±0.7%。AER 和 COMB 方案后血糖立即下降约 16%，持续约 3 小时。比较两种运动方式，运动后 24 小时内血糖水平、血糖方差和血糖变异系数的反应相似。在符号分析中，仅在 COMB 后观察到 0 V 模式（COMB，67.0±7.1 与 76.0±6.3，P=0.003）的增加和 1 V 模式（COMB，29.1±5.3 与 21.5±5.1，P=0.004）的减少。
AER 和 COMB 运动方式在短时间内均可降低血糖水平。非常规分析的使用表明，单次联合运动后血糖变异性降低。
有氧运动、有氧结合抗阻运动和 2 型糖尿病的血糖谱（CGMS）（CGMS 运动）。ClinicalTrials.gov ID：NCT00887094。
