Fagard R, Staessen J
Department of Pathophysiology, Faculty of Medicine, University of Leuven, Belgium.
Am J Cardiol. 1991 Mar 15;67(7):585-9. doi: 10.1016/0002-9149(91)90896-s.
It has been suggested that the decline of cardiac output with age is due to increased prevalence of disease, particularly occult coronary artery disease. Therefore, the relation of cardiac output (direct oxygen Fick method) to age was analyzed in 110 sixteen- to 64-year-old men with World Health Organization stage I or II essential hypertension at the time of the hemodynamic study, who were alive and free of cardiovascular complications 7 years later. At supine and seated rest, during upright bicycle exercise at 50 W and and at peak work load, cardiac output was inversely (p less than 0.01) related to age. These relations were independent of weight and mean intraarterial pressure. Stroke volume decreased with advancing age at supine rest, but not at rest and during exercise in the seated position. Heart rate was not affected by age in the supine position, but was slower in older patients during upright rest and at peak exercise. In conclusion, in patients with essential hypertension who remained free of cardiovascular complications for 7 years, cardiac output was independently and inversely related to age at various levels of activity. These findings suggest that occult cardiovascular disease does not explain the decline in cardiac output with age in patients with essential hypertension.
有人提出，心输出量随年龄下降是由于疾病患病率增加，尤其是隐匿性冠状动脉疾病。因此，在110名年龄在16至64岁之间、在进行血流动力学研究时处于世界卫生组织I期或II期原发性高血压的男性中，分析了心输出量（直接氧Fick法）与年龄的关系，这些男性在7年后仍存活且无心血管并发症。在仰卧位和坐位休息时、在50W的直立自行车运动期间以及在峰值工作负荷下，心输出量与年龄呈负相关（p<0.01）。这些关系独立于体重和平均动脉压。在仰卧位休息时，每搏输出量随年龄增长而下降，但在坐位休息和运动期间则不然。仰卧位时心率不受年龄影响，但老年患者在直立休息和峰值运动时心率较慢。总之，在7年无心血管并发症的原发性高血压患者中，心输出量在不同活动水平下与年龄独立且呈负相关。这些发现表明，隐匿性心血管疾病并不能解释原发性高血压患者心输出量随年龄下降的现象。
