Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden.
Eur J Endocrinol. 2010 Mar;162(3):543-50. doi: 10.1530/EJE-09-1006. Epub 2009 Dec 11.
Several smaller studies have indicated that adiponectin might be associated with left ventricular (LV) mass and function, but community-based studies with adequate sample size and adjustment for potential confounders are lacking. Our objective was to investigate such associations in two large community-based studies of elderly.
Cross-sectional.
We evaluated cross-sectional relations between serum adiponectin and echocardiographic measures of cardiac geometry and function (LV mass index, LV relative wall thickness, LV end-diastolic diameter, left atrial diameter, ejection fraction, LV isovolumic relaxation time, and E/A ratio) in 954 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), and in 427 71-year-old men from the Uppsala Longitudinal Study of Adult Men (ULSAM).
In models adjusted for age, sex, body mass index, systolic blood pressure, antihypertensive treatment, antidiabetic treatment, lipid-lowering medication, fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, creatinine, and smoking, adiponectin was inversely associated with ejection fraction in men (beta, -1.62; 95% confidence interval (CI), -2.50, -0.75 in PIVUS; beta, -1.35; 95% CI, -2.41, -0.29 in ULSAM), but not in women. After additional adjustment for N-terminal pro-brain natriuretic peptide (NT-proBNP), the association between adiponectin and ejection fraction was attenuated (beta, -0.98; 95% CI, -1.86, -0.10 in PIVUS; beta, -0.75; 95% CI, -1.84, 0.35 in ULSAM).
Serum adiponectin concentrations were associated with ejection fraction in men, and these associations were partially attenuated by NT-proBNP. Our results imply that adiponectin may be associated with systolic function through pathways that involve natriuretic peptides.
一些较小的研究表明脂联素可能与左心室（LV）质量和功能有关，但缺乏基于社区的、具有足够样本量且调整了潜在混杂因素的研究。我们的目的是在两项大型基于社区的老年人研究中调查这种相关性。
横断面研究。
我们评估了血清脂联素与超声心动图测量的心脏几何形状和功能（LV 质量指数、LV 相对壁厚度、LV 舒张末期直径、左心房直径、射血分数、LV 等容舒张时间和 E/A 比值）之间的横断面关系，共纳入了 954 名 70 岁（50%为女性）的 Prospective Investigation of the Vasculature in Uppsala Seniors（PIVUS）参与者和 427 名 71 岁的 Uppsala Longitudinal Study of Adult Men（ULSAM）男性参与者。
在调整了年龄、性别、体重指数、收缩压、降压治疗、降糖治疗、降脂药物、空腹血糖、总胆固醇、高密度脂蛋白胆固醇、肌酐和吸烟因素后，脂联素与男性的射血分数呈负相关（PIVUS 中 beta 值为-1.62；95%置信区间（CI）为-2.50，-0.75；ULSAM 中 beta 值为-1.35；95%CI 为-2.41，-0.29），但在女性中则没有。在进一步调整 N 末端脑利钠肽前体（NT-proBNP）后，脂联素与射血分数的相关性减弱（PIVUS 中 beta 值为-0.98；95%CI 为-1.86，-0.10；ULSAM 中 beta 值为-0.75；95%CI 为-1.84，0.35）。
血清脂联素浓度与男性的射血分数有关，而这些相关性部分被 NT-proBNP 减弱。我们的结果表明，脂联素可能通过涉及利钠肽的途径与收缩功能有关。
