Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hematology Am Soc Hematol Educ Program. 2009:178-84. doi: 10.1182/asheducation-2009.1.178.
The last decade has witnessed an abundance of information detailing the genetic diversity of the RH locus which has exceeded all estimates predicted by serology. Well over 120 RHD and over 60 different RHCE alleles have been documented, and new alleles are still being discovered. For clinical transfusion medicine, RH genetic testing can now be used to determine RHD zygosity, resolve D antigen status, and detect altered RHD and RHCE genes in individuals at risk for producing antibodies to high-incidence Rh antigens, particularly patients with sickle cell disease (SCD).
过去十年见证了大量详细描述 RH 基因座遗传多样性的信息，其丰富程度超过了血清学预测的所有估计。已经记录了超过 120 个 RHD 和超过 60 个不同的 RHCE 等位基因，并且仍在不断发现新的等位基因。对于临床输血医学，RH 基因检测现在可用于确定 RHD 基因型，解决 D 抗原状态，并检测高危人群中产生针对高发 Rh 抗原的抗体的个体中的改变的 RHD 和 RHCE 基因，特别是患有镰状细胞病（SCD）的患者。
