Division of Allergy and Clinical Immunology, Michigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, MI 48109-5648, USA.
Hematology Am Soc Hematol Educ Program. 2009:708-19. doi: 10.1182/asheducation-2009.1.708.
Recent work has suggested that nanoparticles in the form of dendrimers may be a keystone in the future of therapeutics. The field of oncology could soon be revolutionized by novel strategies for diagnosis and therapy employing dendrimer-based nanotherapeutics. Several aspects of cancer therapy would be involved. Diagnosis using imaging techniques such as MRI will be improved by the incorporation of dendrimers as advanced contrast agents. This might involve novel contrast agents targeted specifically to cancer cells. Dendrimers can also be being applied to a variety of cancer therapies to improve their safety and efficacy. A strategy, somewhat akin to the "Trojan horse," involves targeting anti-metabolite drugs via vitamins or hormones that tumors need for growth. Further applications of dendrimers in photodynamic therapy, boron neutron capture therapy, and gene therapy for cancer are being examined. This presentation will cover the fundamentals of research utilizing dendrimers for cancer diagnosis and therapy. An evaluation of this new technologies will detail what advantage dendrimer based therapeutics might have over conventional cancer drugs.
最近的研究表明，树枝状高分子纳米粒子可能成为治疗学未来的关键。基于树枝状高分子的纳米治疗学的新型诊断和治疗策略可能很快会彻底改变肿瘤学领域。癌症治疗的几个方面将会涉及。通过将树枝状高分子作为先进的对比剂纳入成像技术（如 MRI），可以改善诊断。这可能涉及专门针对癌细胞的新型对比剂。树枝状高分子还可以应用于各种癌症治疗方法，以提高其安全性和疗效。一种类似于“特洛伊木马”的策略涉及通过肿瘤生长所需的维生素或激素靶向抗代谢药物。正在研究树枝状高分子在光动力疗法、硼中子俘获疗法和癌症基因治疗中的进一步应用。本演讲将涵盖利用树枝状高分子进行癌症诊断和治疗的研究基础。对这项新技术的评估将详细说明基于树枝状高分子的治疗方法相对于传统癌症药物可能具有哪些优势。
