Department of General Surgery, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, 130041, China.
Department of Rehabilitation Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130000, China.
Stem Cell Res Ther. 2022 Oct 1;13(1):489. doi: 10.1186/s13287-022-03180-9.
Nanomaterials are developing rapidly in the medical field, bringing new hope for treating various refractory diseases. Among them, polymer nanomaterials, with their excellent properties, have been used to treat various diseases, such as malignant tumors, diabetes, and nervous system diseases. Gastrointestinal cancer is among the cancers with the highest morbidity and mortality worldwide. Cancer stem cells are believed to play an important role in the occurrence and development of tumors. This article summarizes the characteristics of gastrointestinal cancer stem cells and reviews the latest research progress in treating gastrointestinal malignant tumors using polymer nanoparticles to target cancer stem cells. In addition, the review article highlights the potential of polymer nanoparticles in targeting gastrointestinal cancer stem cells.
纳米材料在医学领域发展迅速，为治疗各种难治性疾病带来了新的希望。其中，聚合物纳米材料以其优异的性能，已被用于治疗各种疾病，如恶性肿瘤、糖尿病和神经系统疾病。胃肠道癌是全球发病率和死亡率最高的癌症之一。癌症干细胞被认为在肿瘤的发生和发展中起重要作用。本文总结了胃肠道癌干细胞的特征，并综述了利用聚合物纳米颗粒靶向癌症干细胞治疗胃肠道恶性肿瘤的最新研究进展。此外，该综述文章还强调了聚合物纳米颗粒在靶向胃肠道癌干细胞方面的潜力。
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