Wang Bin, Meng Xu
Faculty of Quality Management and Inspection & Quarantine, Yibin University, Yibin 644000, China.
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
Polymers (Basel). 2024 Dec 13;16(24):3481. doi: 10.3390/polym16243481.
Amide-amine (PAMAM) dendrimers are biodegradable, non-immunogenic, genotoxic, and biocompatibible, which make them excellent materials for biological applications. In order to reduce the cytotoxicity of the designed branched molecules, a four-armed branched nucleus (B4) of PAMAM dendrimers as hyperbranched molecules was fused with polyhexamethylene biguanide (PHMB) (A2); hyperbranched polymeric biguanides (PAPBs) with a four-arm central core PAMAM structure were synthesized. The bactericidal and cell toxicity tests showed that PAPB had excellent bactericidal activity against both Gram-positive bacteria and Gram-negative, and the chemical binding of PHMB and PAMAM had synergistic effects. PAMAM reduced the toxicity of PAPB to 3T3 cells.
酰胺-胺（PAMAM）树枝状大分子具有可生物降解、无免疫原性、无基因毒性和生物相容性等特性，这使其成为生物应用的理想材料。为了降低所设计的支化分子的细胞毒性，将PAMAM树枝状大分子的四臂支化核（B4）作为超支化分子与聚六亚甲基双胍（PHMB）（A2）融合；合成了具有四臂中心核PAMAM结构的超支化聚合物双胍（PAPB）。杀菌和细胞毒性测试表明，PAPB对革兰氏阳性菌和革兰氏阴性菌均具有优异的杀菌活性，且PHMB与PAMAM的化学结合具有协同效应。PAMAM降低了PAPB对3T3细胞的毒性。
