破坏降解酶：靶向 Wnt 通路的癌症治疗新途径。
Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.
机构信息
Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.
出版信息
J Mol Cell Biol. 2010 Apr;2(2):70-3. doi: 10.1093/jmcb/mjp040. Epub 2009 Dec 11.
Abstract
A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/beta-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a beta-catenin destructor.
摘要
一项发表在《自然》杂志上的新研究鉴定出一种小分子抑制剂，该抑制剂针对致癌性的 Wnt/β-连环蛋白信号通路，而该通路与许多人类癌症的发生有关。这种抑制剂的作用靶点是一种此前不为人知的细胞内酶——端锚聚合酶（Tankyrase），它可以控制β-连环蛋白降解酶的破坏。
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.端锚聚合酶抑制可使轴蛋白稳定并拮抗Wnt信号通路。
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