Hsing A W, McLaughlin J K, Hrubec Z, Blot W J, Fraumeni J F
Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892.
Am J Epidemiol. 1991 Mar 1;133(5):437-41. doi: 10.1093/oxfordjournals.aje.a115910.
A 26-year follow-up of nearly 250,000 US veterans who responded to a questionnaire revealed 4,607 deaths from prostate cancer, providing the largest number of cases to date for evaluating relation to tobacco habits. Cigarette smokers had a significant increase in relative risk (RR = 1.18; 95% confidence interval 1.09-1.28) and a dose response reaching 1.51 among smokers of 40 or more cigarettes per day. Risks were elevated, but not significantly, among users of smokeless tobacco and pipe/cigar smokers. Despite limited data in the literature to support this finding, our study suggests that cigarette smoking may be related to prostate cancer, perhaps through its effect on sex hormone metabolism.
对近25万名回复问卷的美国退伍军人进行的26年随访显示，有4607人死于前列腺癌，这为评估与吸烟习惯的关系提供了迄今为止最大数量的病例。吸烟者的相对风险显著增加（RR = 1.18；95%置信区间1.09 - 1.28），且对于每天吸烟40支或更多的吸烟者，剂量反应达到1.51。无烟烟草使用者和烟斗/雪茄吸烟者的风险有所升高，但不显著。尽管文献中支持这一发现的数据有限，但我们的研究表明，吸烟可能与前列腺癌有关，也许是通过其对性激素代谢的影响。
