Hsing A W, McLaughlin J K, Hrubec Z, Blot W J, Fraumeni J F
Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892.
Cancer Causes Control. 1990 Nov;1(3):217-21. doi: 10.1007/BF00117473.
The relationship of tobacco use with risk of primary liver cancer was investigated using data from a 26-year mortality follow-up of nearly 250,000 US veterans, mostly from World War I. Significantly increased risks for liver cancer (289 deaths) were associated with most forms of tobacco use, including pipe and cigar smoking. Elevated relative risks (RRs) were seen for current cigarette smokers (RR = 2.4; 95 percent confidence interval [CI] 1.6-3.5) and former cigarette smokers (RR = 1.9, 1.2-2.9). A strong dose-response relationship (P less than 0.001) was found for cigarette smoking, with smokers of 40 or more cigarettes per day having almost a fourfold risk (RR = 3.8, 1.9-8.0). Risks were also found to increase significantly with years of cigarette use and with earlier age at the start of cigarette smoking. These results are consistent with those of other cohort and case-control studies, suggesting that cigarette smoking may be related to the risk of liver cancer.
利用来自近25万名美国退伍军人（大多来自第一次世界大战）的26年死亡率随访数据，研究了烟草使用与原发性肝癌风险之间的关系。大多数形式的烟草使用，包括抽烟斗和雪茄，都与肝癌风险显著增加（289例死亡）相关。当前吸烟者（相对风险[RR]=2.4；95%置信区间[CI]为1.6 - 3.5）和既往吸烟者（RR = 1.9，1.2 - 2.9）的相对风险升高。对于吸烟，发现了强烈的剂量反应关系（P<0.001），每天吸40支或更多香烟的吸烟者风险几乎增加四倍（RR = 3.8，1.9 - 8.0）。还发现风险随着吸烟年限的增加以及开始吸烟时年龄的提前而显著增加。这些结果与其他队列研究和病例对照研究的结果一致，表明吸烟可能与肝癌风险有关。
