Burch K J, Phelps S J, Constance T D
Department of Pharmacy, Le Bonheur Children's Medical Center, Memphis, TN 38103.
Am J Hosp Pharm. 1991 Jan;48(1):92-7.
The effects of the Gemini PC-2 linear peristaltic infusion device on the integrity of packed red blood cells (RBC) and whole blood products are reported. Thirty-eight units of blood products were infused at rates of 999, 100, 50, and 5 mL/hr under simulated clinical conditions. To evaluate the effect of hematocrit on cell survival, fresh and stored packed RBCs preserved with adenine-saline 3 (AS-3) and fresh and stored packed RBCs and fresh and stored whole blood preserved with citrate-phosphate-dextrose-adenine 1 (CPDA-1) were used. No two units tested came from the same donor. Plasma potassium and plasma free hemoglobin concentrations were determined before and after simulated infusion for 80 experimental runs. Preinfusion plasma potassium and free hemoglobin concentrations varied significantly among the blood products. Stored products were associated with higher plasma potassium and free hemoglobin levels than fresh units, both before and after infusion. Concentrations also differed significantly between AS-3-preserved and CPDA-1-preserved fresh and stored packed RBCs. Infusion did not change plasma potassium values appreciably under any conditions. Plasma free hemoglobin increased in the fresh products only. Donor-specific differences were significant for potassium but not for free hemoglobin. There was no significant effect of infusion rate on either biochemical marker. In all the experimental runs, less than 0.01% of cells were lysed. The Gemini PC-2 linear peristaltic infusion device delivered a variety of blood products at a wide range of infusion rates without inducing a substantial degree of hemolysis.
报告了双子星PC - 2线性蠕动输液装置对浓缩红细胞（RBC）和全血制品完整性的影响。在模拟临床条件下，以999、100、50和5 mL/小时的速率输注了38单位的血液制品。为评估血细胞比容对细胞存活的影响，使用了用腺嘌呤盐水3（AS - 3）保存的新鲜和储存的浓缩红细胞，以及用枸橼酸盐 - 磷酸盐 - 葡萄糖 - 腺嘌呤1（CPDA - 1）保存的新鲜和储存的浓缩红细胞和新鲜及储存的全血。所测试的任何两个单位均来自不同供体。在80次模拟输注前后测定血浆钾和血浆游离血红蛋白浓度。输注前血浆钾和游离血红蛋白浓度在不同血液制品之间差异显著。无论输注前后，储存的制品比新鲜制品的血浆钾和游离血红蛋白水平更高。在新鲜和储存的浓缩红细胞中，AS - 3保存的和CPDA - 1保存的之间的浓度也有显著差异。在任何条件下，输注均未明显改变血浆钾值。仅新鲜制品中的血浆游离血红蛋白增加。供体特异性差异在钾方面显著，但在游离血红蛋白方面不显著。输注速率对任何一种生化标志物均无显著影响。在所有实验中，细胞裂解率均低于0.01%。双子星PC - 2线性蠕动输液装置能够在很宽的输注速率范围内输送多种血液制品，且不会引起大量溶血。
