Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
J Nucl Med. 2010 Jan;51(1):66-76. doi: 10.2967/jnumed.108.061499. Epub 2009 Dec 15.
Modern radiotherapy techniques heavily rely on high-quality medical imaging. PET provides biologic information about the tumor, complementary to anatomic imaging. Integrated PET/CT has found its way into the practice of radiation oncology, and (18)F-FDG PET is being introduced for radiotherapy planning. The functional information possibly augments accurate delineation and treatment of the tumor and its extensions while reducing the dose to surrounding healthy tissues. In addition to (18)F-FDG, other PET tracers are available for imaging specific biologic tumor characteristics determining radiation resistance. For head and neck cancer, the potential gains of PET are increasingly being recognized. This review describes the current role of PET and perspectives on its future use for selection and delineation of radiotherapy target volumes and for biologic characterization of this tumor entity. Furthermore, the potential role of PET for early response monitoring, treatment modification, and patient selection is addressed in this review.
现代放射治疗技术严重依赖高质量的医学成像。正电子发射断层扫描（PET）提供了关于肿瘤的生物学信息，与解剖成像互补。集成的 PET/CT 已进入放射肿瘤学的实践中，（18）F-FDG PET 正被引入放疗计划。功能信息可能会增强对肿瘤及其延伸的准确描绘和治疗，同时减少对周围健康组织的剂量。除了（18）F-FDG，还有其他用于成像特定生物学肿瘤特征的 PET 示踪剂，这些特征决定了放射抵抗性。对于头颈部癌症，对 PET 的潜在获益越来越被认识到。本文综述了 PET 的当前作用及其对未来用于选择和描绘放疗靶区以及对肿瘤生物学特征进行描绘的作用。此外，本文还讨论了 PET 在早期反应监测、治疗修改和患者选择方面的潜在作用。
