Abouzied Moheieldin M, Fathala Ahmed, Alsugair Abdulaziz, Muhaideb Ahmad I Al, Qahtani Mohammed H Al
Department of Radiology, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Department of Cyclotron and Radiopharmaceuticals, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
World J Nucl Med. 2017 Oct-Dec;16(4):257-265. doi: 10.4103/wjnm.WJNM_40_17.
Fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) has been playing a pivotal role in tumor imaging for the past 20 years. Head and neck (HN) cancers are a good example that can illustrate such unique role of FDG imaging contributing to the patient's management. In this review article, we will describe the normal physiological distribution of FDG within HN structures focusing on its limitations and pitfalls. In addition, we will be also describing its role in the initial staging and restaging of the disease, particularly with regard to therapy response assessment. Furthermore, its role in the evaluation of patients with malignant cervical adenopathy from an unknown primary will be described. In 2016, the Royal College of Radiologists in its third edition published evidence-based guidelines for PET-CT use in HN cancer emphasizing its rule in all these clinical scenarios that are being described in this review. Finally, we will be highlighting future directions in the field of molecular imaging of HN tumors with a special emphasis on the new PET tracers.
在过去20年里，氟代脱氧葡萄糖（FDG）正电子发射断层扫描-计算机断层扫描（PET-CT）在肿瘤成像中发挥了关键作用。头颈（HN）癌就是一个很好的例子，它能说明FDG成像在患者管理方面的独特作用。在这篇综述文章中，我们将描述FDG在HN结构中的正常生理分布，重点关注其局限性和陷阱。此外，我们还将描述其在疾病初始分期和再分期中的作用，特别是在治疗反应评估方面。此外，还将描述其在评估不明原发灶的恶性颈部淋巴结病患者中的作用。2016年，皇家放射科医师学院在其第三版中发布了关于PET-CT在HN癌中应用的循证指南，强调了其在本综述中所描述的所有这些临床场景中的作用。最后，我们将重点介绍HN肿瘤分子成像领域的未来方向，特别强调新型PET示踪剂。
