Arens A I J, Troost E G C, Schinagl D, Kaanders J H A M, Oyen W J G
Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
Q J Nucl Med Mol Imaging. 2011 Oct;55(5):521-8.
Advances in the field of radiation oncology in the last decade resulted in an increasing number of opportunities to optimize therapy. Increased accuracy to deliver the dose to tumors while sparing normal tissues demands more precise delineation of the tumors. When considering to deliver a boost to more aggressive parts of tumors, intratumoral heterogeneity needs to be assessed accurately. Adaptive radiotherapy demands evaluation of response during the course of radiotherapy, in terms of both volumetric and functional changes. Molecular imaging with fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has found its way into clinical practice for various indications in head and neck cancer and new applications are under investigation. In this review, an overview is provided of the current status and developments of the use of FDG-PET/CT in radiation oncology, describing the current status in radiation treatment planning, adaptation of therapy and the position compared to other imaging techniques.
过去十年间，放射肿瘤学领域取得的进展带来了越来越多优化治疗的机会。在保护正常组织的同时提高向肿瘤输送剂量的准确性，需要更精确地勾勒肿瘤轮廓。当考虑对肿瘤中更具侵袭性的部分进行追加放疗时，需要准确评估肿瘤内的异质性。自适应放疗要求在放疗过程中根据体积和功能变化评估反应。氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）分子成像已在头颈部癌的各种适应症中进入临床实践，并且新的应用正在研究中。在本综述中，概述了FDG-PET/CT在放射肿瘤学中的使用现状和发展，描述了其在放射治疗计划、治疗调整方面的现状以及与其他成像技术相比的地位。
