Ishihara Masahiro, Fujino Yasuhito, Setoguchi Asuka, Takahashi Masashi, Nakashima Ko, Ohno Koichi, Tsujimoto Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo.
J Vet Med Sci. 2010 Apr;72(4):465-70. doi: 10.1292/jvms.09-0283. Epub 2009 Dec 16.
Clinical courses of primary immune-mediated hemolytic anemia (pIMHA) in dogs are highly variable, however, limited information is available to predict their accurate prognoses. To evaluate the prognostic significance of clinical factors and to propose a scoring system to predict prognoses, the medical records of seventy-one dogs with pIMHA were reviewed. Overall mortality rate of dogs with pIMHA was 39% and most of the dogs died within 3 months from diagnosis. Sex, body weight, seasonality, packed corpuscular volume (PCV), platelet count (PLT), total plasma protein (TP), blood urea nitrogen, albumin, total bilirubin, sodium ion, prothrombin time, and fibrin/fibrinogen degradation products before immunosuppressive treatment can influence on survival time in dogs with pIMHA. A prognostic scoring system using a combination of sex, seasonality, PCV, PLT and TP can be statistically significant for raising the accuracy of prognostic prediction. Using the scoring system for prognostication in dogs with pIMHA may enable veterinarians to predict a prognosis easily and accurately.
犬原发性免疫介导性溶血性贫血（pIMHA）的临床病程差异很大，然而，目前可用于预测其准确预后的信息有限。为了评估临床因素的预后意义并提出一种预测预后的评分系统，我们回顾了71只患有pIMHA的犬的病历。患有pIMHA的犬的总体死亡率为39%，大多数犬在诊断后3个月内死亡。免疫抑制治疗前的性别、体重、季节性、红细胞压积（PCV）、血小板计数（PLT）、总血浆蛋白（TP）、血尿素氮、白蛋白、总胆红素、钠离子、凝血酶原时间和纤维蛋白/纤维蛋白原降解产物会影响患有pIMHA的犬的生存时间。使用性别、季节性、PCV、PLT和TP组合的预后评分系统对于提高预后预测的准确性具有统计学意义。使用该评分系统对患有pIMHA的犬进行预后评估可能使兽医能够轻松准确地预测预后。
