Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Autophagy. 2010 Jan;6(1):168-9. doi: 10.4161/auto.6.1.10625. Epub 2010 Jan 13.
Beyond its role as a response to starvation, autophagy has been increasingly implicated as part of the normal mechanisms regulating growth and remodeling of various cells and tissues during development. In recently published work we demonstrate that autophagy promotes synaptic development of the Drosophila larval neuromuscular junction (NMJ). We find that autophagy acts by downregulating an E3 ubiquitin ligase, Highwire (Hiw), which limits NMJ growth via a MAPKKK pathway. A similar role for autophagy in the synaptic remodeling that occurs during learning and memory remains an intriguing possibility.
自噬除了作为对饥饿的反应外，其在调节发育过程中各种细胞和组织的生长和重塑的正常机制中也越来越多地被认为是一个重要组成部分。在最近发表的工作中，我们证明了自噬促进了果蝇幼虫神经肌肉接头（NMJ）的突触发育。我们发现自噬通过下调一种 E3 泛素连接酶 Highwire（Hiw）来发挥作用，Hiw 通过 MAPKKK 途径限制 NMJ 的生长。自噬在学习和记忆过程中发生的突触重塑中是否也具有类似的作用，这仍然是一个有趣的可能性。
