Meirav O, Sutton R A, Fink D, Middleton R, Klein J, Walker V R, Halabe A, Vetterli D, Johnson R R
Department of Physics, University of British Columbia, Vancouver, Canada.
Am J Physiol. 1991 Mar;260(3 Pt 2):F466-9. doi: 10.1152/ajprenal.1991.260.3.F466.
The advent of accelerator mass spectrometry (AMS) now permits the ultrasensitive detection of extremely long-lived isotopes, including 14C, 26Al, and 41Ca. Until now, tracer studies of aluminum kinetics have not been possible because aluminum has only two isotopes, with half-lives of 6.5 min (29Al) and 7 x 10(5) yr (26Al), neither of which is suitable for conventional studies. In a novel experiment we have employed AMS to study aluminum kinetics in a normal rat and a 5/6-nephrectomized rat over a 3-wk period of intravenous injection of a tracer dose of 26Al. Kinetics were similar in the two animals; approximately 75% of intravenously injected tracer 26Al was excreted in the urine in the first 24 h as was approximately 80% after 3 wk. Renal clearance of 26Al was approximately 0.75 ml.min-1.kg body wt-1 in both rats. The results clearly demonstrate the potential of this technique for isotope tracer studies in animals as well as in humans.
加速器质谱法（AMS）的出现使得超灵敏检测极长寿命的同位素成为可能，包括碳-14、铝-26和钙-41。到目前为止，铝动力学的示踪研究一直无法进行，因为铝只有两种同位素，半衰期分别为6.5分钟（铝-29）和7×10⁵年（铝-26），这两种都不适合常规研究。在一项新实验中，我们采用AMS研究了正常大鼠和5/6肾切除大鼠在静脉注射示踪剂量的铝-26后3周内的铝动力学。两只动物的动力学相似；静脉注射的示踪剂铝-26在前24小时内约75%经尿液排出，3周后约80%经尿液排出。两只大鼠中铝-26的肾清除率约为0.75毫升·分钟⁻¹·千克体重⁻¹。结果清楚地证明了该技术在动物以及人类同位素示踪研究中的潜力。
