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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Talbot R J, Newton D, Priest N D, Austin J G, Day J P

AEA Technology, Didcot, Oxon, UK.

Hum Exp Toxicol. 1995 Jul;14(7):595-9. doi: 10.1177/096032719501400707.

Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and major loss in urine (59% up to 1 d), but 27 +/- 7 (s.d.)% was retained in the body at 5 d. Faecal excretion was negligible (1% up to 5 d). 3. The mean results accord with the early metabolic pattern in the single subject of a previous, more extensive study, who had retained 4% of the injection after 3 y. Together, the two studies point to the likelihood of large inter-subject differences in the long-term accumulation of dietary aluminium by populations receiving a given level of daily intake.

六名健康男性志愿者接受了柠檬酸形式的26Al静脉注射。使用加速器质谱法和伽马射线能谱法测定长达5 - 6天内血液和排泄物中示踪剂的水平。2. 血液清除迅速（1天后平均剩余注射量的2%），主要通过尿液排出（1天内达59%），但5天时27±7（标准差）%保留在体内。粪便排泄可忽略不计（5天内为1%）。3. 平均结果与先前一项更广泛研究中单个受试者的早期代谢模式相符，该受试者在3年后保留了注射量的4%。这两项研究共同表明，在摄入给定每日摄入量的人群中，长期累积膳食铝的个体间差异可能很大。

Talbot R J, Newton D, Priest N D, Austin J G, Day J P

AEA Technology, Didcot, Oxon, UK.

Hum Exp Toxicol. 1995 Jul;14(7):595-9. doi: 10.1177/096032719501400707.

Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and major loss in urine (59% up to 1 d), but 27 +/- 7 (s.d.)% was retained in the body at 5 d. Faecal excretion was negligible (1% up to 5 d). 3. The mean results accord with the early metabolic pattern in the single subject of a previous, more extensive study, who had retained 4% of the injection after 3 y. Together, the two studies point to the likelihood of large inter-subject differences in the long-term accumulation of dietary aluminium by populations receiving a given level of daily intake.

六名健康男性志愿者接受了柠檬酸形式的26Al静脉注射。使用加速器质谱法和伽马射线能谱法测定长达5 - 6天内血液和排泄物中示踪剂的水平。2. 血液清除迅速（1天后平均剩余注射量的2%），主要通过尿液排出（1天内达59%），但5天时27±7（标准差）%保留在体内。粪便排泄可忽略不计（5天内为1%）。3. 平均结果与先前一项更广泛研究中单个受试者的早期代谢模式相符，该受试者在3年后保留了注射量的4%。这两项研究共同表明，在摄入给定每日摄入量的人群中，长期累积膳食铝的个体间差异可能很大。