Zafar T A, Weaver C M, Martin B R, Flarend R, Elmore D
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907-1264, USA.
Proc Soc Exp Biol Med. 1997 Oct;216(1):81-5. doi: 10.3181/00379727-216-44159.
Because of the lack of a suitable isotope and a sensitive technique of analysis, aluminum has been studied indirectly using analogs such as 67Ga (t1/2 = 78 hr). Recently, with the development of accelerator mass spectrometry (AMS), it has become possible to use the artificially produced radionuclide of aluminum, aluminum 26 (26AI), (t1/2 = 7.16 x 10(5) years). AMS is used for measuring long-lived and stable isotopes with the sensitivity of an attomole (10(-17) mol). To study aluminum metabolism, 26AlCl3 was administered to rats intraperitoneally (ip) by injection and orally by gavage (n = 3/group). Blood was collected periodically. On Day 8 following perfusion, blood, liver, kidney, femur, brain, and spleen were collected and analyzed for 26AI. Of all the tissues studied, 26AI accumulation was greatest in the bone. 26AI accumulated in tissues as: bone > spleen > kidney approximately liver > brain, but absorption was low (0.97% of dose). AMS offers great potential in AI research as it is the only technique available for tracer aluminum study.
由于缺乏合适的同位素以及灵敏的分析技术，铝的研究一直是通过诸如67Ga（半衰期 = 78小时）等类似物进行间接研究。最近，随着加速器质谱法（AMS）的发展，使用人工制造的铝放射性核素铝26（26Al）（半衰期 = 7.16×10⁵年）进行研究成为可能。AMS用于测量长寿命和稳定同位素，其灵敏度可达阿托摩尔（10⁻¹⁷摩尔）。为研究铝的代谢，将26AlCl₃通过腹腔注射（ip）和灌胃（口服）的方式给予大鼠（每组n = 3）。定期采集血液。在灌注后的第8天，采集血液、肝脏、肾脏、股骨、大脑和脾脏，并分析其中的26Al。在所有研究的组织中，26Al在骨骼中的积累量最大。26Al在组织中的积累情况为：骨骼＞脾脏＞肾脏≈肝脏＞大脑，但吸收率较低（占剂量的0.97%）。由于AMS是唯一可用于示踪铝研究的技术，因此它在铝研究中具有巨大潜力。
