人类血浆脂蛋白代谢的特征：低热量饮食对高脂血症的影响。

The characteristics of human plasma lipoprotein metabolism: influence of low caloric diet on hyperlipidemia.

作者信息

Nanbu S, Yamasaki S, Kimura N, Gohda H, Ageta M, Kariya S, Kamogawa T

出版信息

Adv Exp Med Biol. 1977;82:279-82. doi: 10.1007/978-1-4613-4220-5_64.

PMID:200096

Abstract

We have classified hyperlipidemia into three groups according to different levels of VLDL-TG, and postulated the effect of low calorie-diets on plasma TCh are as follows: 1) Low calorie-diets are effective on VLDL-TG in every type of hyperlipidemia, except hyperlipidemia with VLDL-TG under 180 mg/100ml; 2) There was a reciprocal relation between the decreased amount of plasma TCh and the change VLDL-TG induced by the diet; 3) Catabolism of VLDL was accelerated by an increased esterification of VLDL-FC; 4) In the the group with VLDL-TG less than or equal to 180 mg/100ml, the LDC showed a high level of TCh: protein ration, and in the group with VLDL-TG greater than or equal to 260 mg/100ml, there was to be low level of TG: protein ratio in VLDL: 5) In hyperlipidemia with plasma TCh unchanged by the diet LDL-TCh increased significantly without any increase in LDL protein and LDL-TG.

摘要

我们根据极低密度脂蛋白甘油三酯（VLDL-TG）的不同水平将高脂血症分为三组，并推测低热量饮食对血浆总胆固醇（TCh）的影响如下：1）低热量饮食对除VLDL-TG低于180mg/100ml的高脂血症外的每种类型高脂血症的VLDL-TG均有效；2）血浆TCh降低量与饮食诱导的VLDL-TG变化之间存在反比关系；3）VLDL-游离胆固醇（VLDL-FC）酯化增加加速了VLDL的分解代谢；4）在VLDL-TG小于或等于180mg/100ml的组中，低密度脂蛋白胆固醇（LDC）显示出高水平的TCh：蛋白质比值，而在VLDL-TG大于或等于260mg/100ml的组中，VLDL中的甘油三酯：蛋白质比值较低；5）在饮食后血浆TCh无变化的高脂血症中，低密度脂蛋白胆固醇（LDL-TCh）显著增加，而LDL蛋白质和LDL-甘油三酯（LDL-TG）均无增加。