以色列犹太妇女宫颈癌中 CYP1A1 和 CYP2D6 基因多态性。
CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
机构信息
Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
出版信息
Int J Gynecol Cancer. 2009 Nov;19(8):1300-2. doi: 10.1111/IGC.0b013e3181b9fa5d.
HYPOTHESIS
To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
METHODS
Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.
RESULTS
The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).
CONCLUSION
CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.
假设
评估以色列犹太妇女宫颈癌中 CYP1A1 和 CYP2D6 基因多态性的频率分布。
方法
评估了 43 名以色列犹太宫颈癌妇女和 123 名健康的以色列犹太妇女。使用等位基因特异性聚合酶链反应方法分析 CYP1A1（2 个等位基因）和 CYP2D6 多态性。
结果
CYP1A1（2 个等位基因）和 CYP2D6 多态性的等位基因频率和基因型分布未达到显著水平。吸烟是宫颈癌的唯一独立危险因素（P = 0.0003）。
结论
在以色列犹太人群中，CYP1A1 和 CYP2D6 突变与宫颈癌风险增加无关。
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