Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Int J Gynecol Cancer. 2009 Nov;19(8):1300-2. doi: 10.1111/IGC.0b013e3181b9fa5d.
To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.
The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).
CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.
评估以色列犹太妇女宫颈癌中 CYP1A1 和 CYP2D6 基因多态性的频率分布。
评估了 43 名以色列犹太宫颈癌妇女和 123 名健康的以色列犹太妇女。使用等位基因特异性聚合酶链反应方法分析 CYP1A1（2 个等位基因）和 CYP2D6 多态性。
CYP1A1（2 个等位基因）和 CYP2D6 多态性的等位基因频率和基因型分布未达到显著水平。吸烟是宫颈癌的唯一独立危险因素（P = 0.0003）。
在以色列犹太人群中，CYP1A1 和 CYP2D6 突变与宫颈癌风险增加无关。
