Arbel-Alon S, Menczer J, Feldman N, Glezerman M, Yeremin L, Friedman E
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel.
Int J Gynecol Cancer. 2002 Nov-Dec;12(6):741-4. doi: 10.1046/j.1525-1438.2002.01124.x.
Recently it has been found that the presence of homozygous arginine polymorphism at codon 72 of p53, represents a significant risk factor in the development of HPV-associated cervical cancer. The incidence of cervical carcinoma is persistently very low in Israeli Jewish women for unknown reasons. The incidence among those of North African origin is relatively higher. The aim of the present study was to assess the frequency distribution of the p53 homozygous arginine polymorphism in cervical cancer patients and in a population sample of healthy Israeli Jewish women in order to determine whether the incidence pattern among them is genetically based. The cases consisted of 23 Israeli Jewish patients with histologically confirmed squamous cell carcinoma of the cervix. A group of 162 randomly chosen Israeli Jewish healthy participants, considered to represent the general population, comprised the controls. The germline p53 polymorphism at codon 72 was determined by PCR in DNA obtained from a blood sample taken from each subject. Homozygous arginine was found in 34.8% of cases and in only 14.8% of controls. This difference was statistically significant (P = 0.01). The frequency of homozygous arginine polymorphism in controls was lower than in any other population hitherto reported. It was significantly more common among those of North African than among those of other origin (30.3% vs. 10.8%; P < 0.01). It may be assumed that the low incidence of cervical cancer in Israeli Jewish women and the differences between the ethnic groups may be related to the frequency pattern of the homozygous arginine p53 polymorphism
最近发现，p53基因第72位密码子存在纯合精氨酸多态性是HPV相关宫颈癌发生的一个重要危险因素。以色列犹太女性宫颈癌的发病率一直很低，原因不明。北非裔女性的发病率相对较高。本研究的目的是评估宫颈癌患者和以色列犹太健康女性人群样本中p53纯合精氨酸多态性的频率分布，以确定她们之间的发病模式是否基于遗传因素。病例包括23名经组织学确诊为宫颈鳞状细胞癌的以色列犹太患者。一组162名随机选择的以色列犹太健康参与者作为对照组，他们被认为代表了一般人群。通过聚合酶链反应（PCR）检测每个受试者血样中DNA的p53基因第72位密码子的种系多态性。在34.8%的病例中发现了纯合精氨酸，而在对照组中仅为14.8%。这种差异具有统计学意义（P = 0.01）。对照组中纯合精氨酸多态性的频率低于迄今报道的任何其他人群。在北非裔人群中比在其他血统人群中更为常见（30.3%对10.8%；P < 0.01）。可以推测，以色列犹太女性宫颈癌的低发病率以及不同种族之间的差异可能与p53纯合精氨酸多态性的频率模式有关
