Ding Bo, Sun Wei, Han Suping, Cai Yunlang, Ren Mulan, Shen Yang
Department of Gynecology and Obstetrics, Zhongda Hospital, School of Medicine, Southeast University Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Medicine (Baltimore). 2018 Mar;97(13):e0210. doi: 10.1097/MD.0000000000010210.
This meta-analysis aims to examine whether the MspI and Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) are associated with cervical cancer risk.
Eligible case-control studies were identified dated until July 2017. Pooled odds ratios (ORs) were used to assess the strength of the association between the two variants and cervical cancer risk.
Thirteen studies were eligible (2148 cases and 2252 controls) concerning MspI polymorphism and 8 studies were eligible (1466 cases and 1690 controls) for Ile462Val polymorphism. MspI polymorphism seemed to result in cervical cancer risk in any genetic model (C allele vs T allele: OR = 1.44, 95% confidence interval [CI] = 1.16-1.79; heterozygous model: OR = 1.40, 95% CI = 1.08-1.82; homozygous model: OR = 2.22, 95% CI = 1.48-3.33, dominant model: OR = 1.50, 95% CI = 1.14-1.98 and recessive model: OR = 1.80, 95% CI = 1.35-2.41); similar significantly increased risk was found among Caucasians and Asians. Ile462Val polymorphism was associated with elevated cervical cancer risk (Val allele vs Ile allele: OR = 1.85, 95% CI = 1.27-2.67; heterozygous model: OR = 1.42, 95% CI = 1.28-1.61; homozygous model: OR = 2.94, 95% CI = 1.15-7.54; dominant model: OR = 2.00, 95% CI = 1.33-3.00); this finding was replicated upon Caucasian population.
This meta-analysis demonstrated that polymorphisms in MspI and Ile462Val of CYP1A1 were risk factors for developing cervical cancer.
本荟萃分析旨在研究细胞色素P450 1A1（CYP1A1）的MspI和Ile462Val多态性是否与宫颈癌风险相关。
确定截至2017年7月的符合条件的病例对照研究。采用合并比值比（OR）评估这两种变异与宫颈癌风险之间关联的强度。
关于MspI多态性的有13项研究符合条件（2148例病例和2252例对照），关于Ile462Val多态性的有8项研究符合条件（1466例病例和1690例对照）。在任何遗传模型中，MspI多态性似乎都会导致宫颈癌风险增加（C等位基因与T等位基因：OR = 1.44，95%置信区间[CI] = 1.16 - 1.79；杂合子模型：OR = 1.40，95% CI = 1.08 - 1.82；纯合子模型：OR = 2.22，95% CI = 1.48 - 3.33，显性模型：OR = 1.50，95% CI = 1.14 - 1.98，隐性模型：OR = 1.80，95% CI = 1.35 - 2.41）；在白种人和亚洲人群中也发现了类似的显著增加的风险。Ile462Val多态性与宫颈癌风险升高相关（Val等位基因与Ile等位基因：OR = 1.85，95% CI = 1.27 - 2.67；杂合子模型：OR = 1.42，95% CI = 1.28 - 1.61；纯合子模型：OR = 2.94，95% CI = 1.15 - 7.54；显性模型：OR = 2.00，95% CI = 1.33 - 3.00）；这一发现在白种人群中得到了重复验证。
本荟萃分析表明，CYP1A1的MspI和Ile462Val多态性是宫颈癌发生的危险因素。
