Wang Li-Na, Wang Fen, Liu Jie, Jin Ying-Hui, Fang Cheng, Ren Xue-Qun
Department of Gynaecology, Huaihe Hospital of Henan University, Kaifeng, China.
Center for Evidence-Based Medicine, Henan University, Kaifeng, China.
Front Physiol. 2017 Dec 18;8:1081. doi: 10.3389/fphys.2017.01081. eCollection 2017.
Previous studies have reported that Ile462Val polymorphism in the gene Cytochrome P450 1A1 () is associated with the risk of cervical cancer, but inconsistent results have emerged. Hence, we performed this updated and cumulative meta-analysis to ascertain a more accurate association between Ile462Val polymorphism and risk of cervical cancer. Studies involving the Ile462Val polymorphism associated with cervical cancer risk were searched from the databases of PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI). The strength of correlation was evaluated through calculating summary odds ratios (ORs) with the corresponding 95% confidence intervals (95% CIs). Subgroup analyses according to ethnicity, source of control and HWE were completed to further explore specific association between the polymorphism and the cancer risk. Altogether, 11 eligible case-control studies were ultimately encompassed into the current meta-analysis, with 1,932 patients and 2,039 healthy controls. The total analysis revealed a borderline relationship between Ile462Val polymorphism and cervical cancer risk in general population. Interestingly, after subgroup analyses based on ethnicity and source of control, the polymorphism increased the susceptibility of cervical cancer in Caucasian (G vs. A: OR = 1.97, 95% CI = 1.24-3.13; GG vs. AA: OR = 3 .24, 95% CI = 1.24-8.46; GA vs. AA: OR = 1.62, 95% CI = 1.25-2.10; GA+GG vs. AA: OR = 1.68, 95% CI = 1.16-2.43; GG vs. AA+GA: OR = 2.73, 95% CI = 1.05-7.10) and population-based (G vs. A: OR = 1.49, 95% CI = 1.10-2.02; GA vs. AA: OR = 1.41, 95% CI = 1.20-1.67; GA+GG vs. AA: OR = 1.40, 95% CI = 1.19-1.64) groups. The Ile462Val polymorphism may enhance the susceptibility to cervical cancer in Caucasian females.
以往研究报道，细胞色素P450 1A1（CYP1A1）基因中的Ile462Val多态性与宫颈癌风险相关，但结果并不一致。因此，我们进行了这项更新的累积荟萃分析，以确定Ile462Val多态性与宫颈癌风险之间更准确的关联。我们从PubMed、Scopus、ScienceDirect和中国知网（CNKI）数据库中检索了涉及Ile462Val多态性与宫颈癌风险相关的研究。通过计算汇总比值比（OR）及其相应的95%置信区间（95%CI）来评估相关性强度。根据种族、对照来源和哈迪-温伯格平衡（HWE）进行亚组分析，以进一步探讨该多态性与癌症风险之间的具体关联。最终，共有11项符合条件的病例对照研究纳入了当前的荟萃分析，包括1932例患者和2039例健康对照。总体分析显示，Ile462Val多态性与一般人群的宫颈癌风险之间存在临界关系。有趣的是，在基于种族和对照来源的亚组分析后，该多态性增加了白种人（G vs. A：OR = 1.97，95%CI = 1.24 - 3.13；GG vs. AA：OR = 3.24，95%CI = 1.24 - 8.46；GA vs. AA：OR = 1.62，95%CI = 1.25 - 2.10；GA + GG vs. AA：OR = 1.68，95%CI = 1.16 - 2.43；GG vs. AA + GA：OR = 2.73，95%CI = 1.05 - 7.10）和基于人群（G vs. A：OR = 1.49，95%CI = 1.10 - 2.02；GA vs. AA：OR = 1.41，95%CI = 1.20 - 1.67；GA + GG vs. AA：OR = 1.40，95%CI = 1.19 - 1.64）组患宫颈癌的易感性。Ile462Val多态性可能会增加白种女性患宫颈癌的易感性。
