Yox D P, Stokesberry H, Ritter R C
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164-6520.
Am J Physiol. 1991 Mar;260(3 Pt 2):R503-8. doi: 10.1152/ajpregu.1991.260.3.R503.
The ability of intraintestinal nutrient infusions to suppress sham feeding was examined in intact rats and in rats with total subdiaphragmatic vagal transections. Vagotomy abolished the suppression of sham feeding by intraintestinal infusion of maltose or oleate. Suppression of sham feeding by intraintestinal L-phenylalanine was reduced but not abolished by vagotomy. The results of this examination indicate that the vagus nerve mediates suppression of the sham feeding by intraintestinal maltose and oleate but is only partially responsible for suppression of food intake produced by L-phenylalanine. Taken together with previously published data these results suggest that effects on feeding by specific nutrients may be mediated by anatomically distinct populations of visceral afferent neurons.
在完整大鼠和膈下迷走神经完全横断的大鼠中，研究了肠内营养输注抑制假饲的能力。迷走神经切断术消除了肠内输注麦芽糖或油酸盐对假饲的抑制作用。肠内L-苯丙氨酸对假饲的抑制作用在迷走神经切断术后有所减弱但并未消除。该研究结果表明，迷走神经介导了肠内麦芽糖和油酸盐对假饲的抑制作用，但仅部分负责L-苯丙氨酸引起的食物摄入量的抑制。结合先前发表的数据，这些结果表明特定营养素对进食的影响可能由解剖学上不同的内脏传入神经元群体介导。
