Ciucanu Cristian Ionuţ, Raţiu Sonia, Olariu Sorin, Ciucanu Ionel
Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes" of Timişoara, Timişoara, Romania.
Department of Chemistry, West University of Timisoara, Timişoara, Romania.
Aesthetic Plast Surg. 2025 Sep 4. doi: 10.1007/s00266-025-05186-z.
Wound healing is a current problem in surgery. Wounds most commonly occur from surgery, accidents, and burns. The purpose of this study was to reduce bleeding time and wound healing time as well as prevent or mitigate scarring by applying D-mannose with calcium propionate mixtures directly to the wound in powder form.
This study was a placebo, randomized, double-blind, crossover experiment involving a single group of twenty-five subjects. The number of incisions made was equal to the number of treatments required. Each subject had one incision per day. Only one treatment was applied to each wound. By the end, each subject was treated with all test mixtures and the placebo substance.
The results show that the bleeding time can be reduced to about 50% compared to D-mannose when treating the wound with a mixture containing 20-60 moles of D-mannose per 1 mole of powdered calcium propionate. The wound healing time was reduced by about 40% compared to D-mannose. No visible scarring was observed after 40 days on skin treated with the mannose and calcium propionate mixture.
Bleeding time can be reduced by approximately 50% when the wound is treated with a mixture containing 40 moles of D-mannose per 1 mole of calcium propionate and wound healing time by approximately 40% compared to D-mannose. Both substances contribute to the destruction of pathogens and to the processes of new tissue formation, which accelerates the healing process. Treatment with this powdered mixture prevents skin scarring.
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伤口愈合是当前外科手术中的一个问题。伤口最常见于手术、事故和烧伤。本研究的目的是通过将D-甘露糖与丙酸钙混合物以粉末形式直接应用于伤口，来减少出血时间和伤口愈合时间，并预防或减轻瘢痕形成。
本研究是一项安慰剂对照、随机、双盲、交叉实验，涉及一组25名受试者。切口数量与所需治疗次数相等。每个受试者每天有一个切口。每个伤口仅应用一种治疗方法。到最后，每个受试者都接受了所有测试混合物和安慰剂物质的治疗。
结果表明，当用每1摩尔丙酸钙粉末含有20 - 60摩尔D-甘露糖的混合物治疗伤口时，与单独使用D-甘露糖相比，出血时间可减少约50%。与单独使用D-甘露糖相比，伤口愈合时间减少了约40%。用甘露糖和丙酸钙混合物处理的皮肤在40天后未观察到明显瘢痕形成。
当用每1摩尔丙酸钙含有40摩尔D-甘露糖的混合物治疗伤口时，出血时间可减少约50%，与单独使用D-甘露糖相比，伤口愈合时间减少约40%。这两种物质都有助于破坏病原体和新组织形成过程，从而加速愈合过程。用这种粉末混合物治疗可防止皮肤瘢痕形成。
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