Transplant Unit, Department of Internal Medicine, Vita-Salute San Raffaele University, Milano, Italy.
Curr Opin Organ Transplant. 2010 Feb;15(1):119-23. doi: 10.1097/MOT.0b013e32833552bc.
Type 1 diabetes is a chronic disease that can impact patient survival and quality of life because of acute and chronic complications. Although intensive insulin scheme treatment has been shown to reduce the incidence of diabetes-related complications, only pancreas transplantation has been shown to be able to alter them and in some cases to revert them. In this review, an extensive view of the effect of pancreas transplantation on diabetes-related complication will be described.
This review will focus on patients survival, diabetic nephropathy, neuropathy, cardiovascular event, comparing their incidence in type 1 diabetic patients treated with insulin and in type 1 diabetic patients receiving kidney, kidney-pancreas or pancreas alone graft. The review will focus mostly on the papers published in the last decade, with a particular attention to those on new aspects of graft function analysis like spectroscopy. Moreover, a comparison with islet transplantation procedure will be performed.
This review will give an update on the potential of pancreas transplantation, give a guide for clinical practice and help to consider pancreas transplantation as an alternative to insulin treatment for selected patients.
1 型糖尿病是一种慢性疾病，由于急性和慢性并发症，会影响患者的生存和生活质量。尽管强化胰岛素方案治疗已被证明可以降低糖尿病相关并发症的发生率，但只有胰腺移植才能改变这些并发症，在某些情况下还可以逆转这些并发症。在这篇综述中，将广泛描述胰腺移植对糖尿病相关并发症的影响。
本综述将重点关注患者的生存率、糖尿病肾病、神经病变、心血管事件，并比较接受胰岛素治疗的 1 型糖尿病患者和接受肾、肾胰或单纯胰腺移植的 1 型糖尿病患者的这些并发症的发生率。综述将主要关注过去十年发表的论文，特别关注关于移植物功能分析新方面的论文，如光谱分析。此外，还将与胰岛移植手术进行比较。
本综述将提供关于胰腺移植潜力的最新信息，为临床实践提供指导，并有助于将胰腺移植作为某些患者替代胰岛素治疗的一种选择。
