Department of Ophthalmology, Azienda Ospedaliero-Universitaria "Santa Maria della Misericordia," Udine, Italy.
J Glaucoma. 2009 Dec;18(9):658-61. doi: 10.1097/IJG.0b013e31819c4893.
To investigate short-term effect on intraocular pressure (IOP) after intravitreal injection of ranibizumab (Lucentis) (IVIL).
This prospective study included 1 eye of 54 patients (64+/-12 y) with wet age-related macular degeneration treated with IVIL. IOP measurements with TonoPen were taken: immediately before and 5 seconds, 5, 10, 15, 30, 60 minutes, and 1 day after IVIL. Axial length (with ultrasound biometry) was assessed in 24 eyes. The analysis included IOP difference at various time points and between phakic and pseudophakic eyes and the relationship between axial length and IOP increases after 5 seconds.
Mean IOP were 16.3+/-3.0 mm Hg (range: 12.0 to 21.3), 44.1+/-10.6 (22.0 to 59.3), 29.0+/-9.6 (15.0 to 49.0), 25.8+/-7.9 (16.0 to 45.0), 23.7+/-6.6 (15.7 to 39.0), 21.9+/-5.6 (14.7 to 37.0), 18.8+/-6.1 (10.0 to 35.0), and 16.1+/-3.0 (11.0 to 21.0), respectively, for time points immediately before, 5 seconds, 5, 10, 15, 30, 60 minutes, and 1 day after IVIL. Differences between before IVIL and after IVIL IOP were statistically significant after 5 seconds, 5, 10, 15, and 30 minutes (P=0.0001); however, were not significant after 1 hour (P=0.064) and 1 day (P=0.449). Differences between phakic and pseudophakic eyes were not significant (P>0.05). The relationship between shorter axial length and IOP increase after 5 seconds was significant (linear regression analysis; R=0.28, P=0.007).
IVIL causes a considerable short-term transient rise in IOP. The IOP increase after IVIL can be statistically significant at 0 to 30 minutes after injection in both phakic and pseudophakic eyes, and tends to be greater in shorter eyes.
研究玻璃体内注射雷珠单抗（Lucentis）后对眼内压（IOP）的短期影响。
本前瞻性研究纳入了 54 例（64+/-12 岁）湿性年龄相关性黄斑变性患者的 1 只眼，均接受玻璃体内注射雷珠单抗治疗。使用 TonoPen 测量眼压：注射前即刻和注射后 5 秒、5、10、15、30、60 分钟和 1 天。在 24 只眼中评估眼轴长度（使用超声生物测量法）。分析包括不同时间点的眼压差异、有晶状体眼和无晶状体眼之间的差异以及注射后 5 秒时眼轴长度与眼压升高之间的关系。
平均眼压分别为 16.3+/-3.0mmHg（范围：12.0 至 21.3）、44.1+/-10.6mmHg（22.0 至 59.3）、29.0+/-9.6mmHg（15.0 至 49.0）、25.8+/-7.9mmHg（16.0 至 45.0）、23.7+/-6.6mmHg（15.7 至 39.0）、21.9+/-5.6mmHg（14.7 至 37.0）、18.8+/-6.1mmHg（10.0 至 35.0）和 16.1+/-3.0mmHg（11.0 至 21.0），分别为注射前即刻、注射后 5 秒、5、10、15、30、60 分钟和 1 天的眼压。与注射前相比，注射后 5 秒、5、10、15 和 30 分钟时眼压差异有统计学意义（P=0.0001）；然而，在 1 小时（P=0.064）和 1 天（P=0.449）时差异无统计学意义。有晶状体眼和无晶状体眼之间的差异无统计学意义（P>0.05）。5 秒时较短的眼轴长度与眼压升高之间的关系具有显著意义（线性回归分析；R=0.28，P=0.007）。
玻璃体内注射雷珠单抗可导致明显的短期眼压一过性升高。在有晶状体眼和无晶状体眼中，注射后 0 至 30 分钟时眼压升高具有统计学意义，且在较短眼轴中更明显。
