Department of Ophthalmology, Karabuk University Faculty of Medicine, Karabuk, Turkiye.
Middle East Afr J Ophthalmol. 2024 Jun 14;30(2):85-88. doi: 10.4103/meajo.meajo_177_23. eCollection 2023 Apr-Jun.
The objective of the study was to examine the effect of dorzolamide-timolol (DT) eye drop used before intravitreal ranibizumab (IVR) injection on intraocular pressure (IOP) change.
50 eyes of 50 patients who received DT eye drops 1 h before IVR injection due to diabetic retinopathy and macular edema were considered Group 1, and 50 eyes of 50 patients who did not receive DT eye drops were considered Group 2. Those patients who had previously undergone intravitreal injection had intraocular surgery, and used any eye drops were not included in the study. Before the injection, IO values were measured with a Tonopen contact handheld tonometer before the blepharostat was placed (BIOP), after the blepharostat was placed (AIOP), and at the 1 min after the injection (IIOP).
There were 25 males and 25 females in Group 1 and 25 males and 25 females in Group 2; the mean age was 65.66 ± 9.94 years in Group 1 and 65.54 ± 7.43 years in Group 2 ( = 0.98). In Group 1, BIOP was 18.91 ± 18.91, AIOP was 21.62 ± 6.16 mmHg, and IIOP was 49.21 ± 10.95 mmHg. In Group 2, BIOP was 20.18 ± 4.19 mmHg, AIOP was 24.60 ± 4.90 mmHg, and IIOP was 49.96 ± 9.72 mmHg. IIOP-BIOP difference was 30.30 ± 9.85 mmHg in Group 1 and 29.78 ± 9.33 mmHg in Group 2 and the difference was not statistically significant ( = 0.78). In Group 1, the IIOP-AIOP difference was 27.58 ± 10.60 mmHg and in Group 2, 25.36 ± 10.46 mmHg. The difference between IIOP and AIOP was not statistically significant ( = 0.27).
The use of topical DT eye drops before IVR injection does not affect the intraocular pressure change.
本研究旨在探讨在玻璃体内注射雷珠单抗（IVR）前使用多佐胺-噻吗洛尔（DT）滴眼剂对眼压（IOP）变化的影响。
因糖尿病视网膜病变和黄斑水肿而在 IVR 注射前使用 DT 滴眼剂 1 小时的 50 只眼（50 例患者）被归入第 1 组，未使用 DT 滴眼剂的 50 只眼（50 例患者）归入第 2 组。那些之前已经接受过玻璃体内注射、眼部手术或使用过任何眼药水的患者都不包括在研究范围内。在注射前，使用 Tonopen 接触式手持眼压计测量下睑器放置前（BIOP）、放置后（AIOP）和注射后 1 分钟（IIOP）的眼内压值。
第 1 组有 25 名男性和 25 名女性，第 2 组有 25 名男性和 25 名女性；第 1 组的平均年龄为 65.66 ± 9.94 岁，第 2 组为 65.54 ± 7.43 岁（ = 0.98）。第 1 组 BIOP 为 18.91 ± 18.91mmHg，AIOP 为 21.62 ± 6.16mmHg，IIOP 为 49.21 ± 10.95mmHg。第 2 组 BIOP 为 20.18 ± 4.19mmHg，AIOP 为 24.60 ± 4.90mmHg，IIOP 为 49.96 ± 9.72mmHg。第 1 组 IIOP-BIOP 差值为 30.30 ± 9.85mmHg，第 2 组为 29.78 ± 9.33mmHg，差异无统计学意义（ = 0.78）。第 1 组 IIOP-AIOP 差值为 27.58 ± 10.60mmHg，第 2 组为 25.36 ± 10.46mmHg。IIOP 与 AIOP 之间的差异无统计学意义（ = 0.27）。
在 IVR 注射前使用局部 DT 滴眼剂不会影响眼压变化。
