Oncologic Centre, Karolinska University Hospital, Stockholm, Sweden.
Eur J Cancer Prev. 2010 Mar;19(2):87-93. doi: 10.1097/CEJ.0b013e32833548ed.
The objective of this study was to assess detection rates and interval breast cancer (IC) rates from eight programmes in the European Breast Cancer Screening Network. A common data collection protocol was used to explore differences in IC rates among programmes and discuss their potential determinants. Pooled analysis was used to describe IC rates by age, compliance in screening, recall rate, screening detection (SD) rate and expected breast cancer incidence. Participation in screening averaged 77.9% (range 42.6-88.7%), recall rate 5.4% (range 3.3-17.7%) in the initial and 3.4% (range 1.8-8.9%) in the subsequent screening rounds, and SD rate was 60.4 (range 41.6-91) per 10 000 women in initial and 38.5 (range 31.3-62.6) in subsequent screens. IC rate during first 12 months after screening was 5.9 (range 2.1-7.3) per 10 000 women screened negative and 12.6 (range 6.3-15) in the second year of the interval. IC comprised 28% of the IC and SD cancers. The ratio between IC rate and expected incidence was 0.29 for the first 12 months and 0.63 for the 13-24 months period. Sensitivity was higher for the ages 60-69 years and for initial tests than subsequent tests. There were distinct differences in the IC rates between programmes. The results of this study reveal large variations in screening sensitivity and performance. Pooled evaluation of some process indicators within the European breast cancer screening programmes proved to be feasible and is likely to be useful for the future, particularly if it is performed regularly and extensively.
本研究的目的是评估欧洲乳腺癌筛查网络中 8 个项目的检出率和间期乳腺癌（IC）率。使用通用的数据收集方案来探讨项目之间 IC 率的差异，并讨论其潜在的决定因素。采用汇总分析描述了按年龄、筛查依从性、召回率、筛查检出率（SD）和预期乳腺癌发病率划分的 IC 率。筛查的平均参与率为 77.9%（范围为 42.6-88.7%），初筛的召回率为 5.4%（范围为 3.3-17.7%），随后筛查的召回率为 3.4%（范围为 1.8-8.9%），SD 率为每 10000 名女性初筛 60.4（范围为 41.6-91），随后筛查 38.5（范围为 31.3-62.6）。在筛查后的 12 个月内，IC 率为每 10000 名阴性筛查女性 5.9（范围为 2.1-7.3），第二年为 12.6（范围为 6.3-15）。IC 占 IC 和 SD 癌的 28%。前 12 个月的 IC 率与预期发病率的比值为 0.29，第 13-24 个月的比值为 0.63。60-69 岁年龄组和初筛的敏感性高于后续筛查。项目之间的 IC 率存在明显差异。本研究结果表明，筛查的敏感性和效能存在很大差异。对欧洲乳腺癌筛查项目的一些过程指标进行汇总评估是可行的，并且可能对未来有用，特别是如果定期广泛进行。
