Department of General Surgery, Namik Kemal University, School of Medicine, Tekirdag, Turkey.
Department of Public Health, Marmara University School of Medicine, Istanbul, Turkey.
Diagn Interv Radiol. 2021 Mar;27(2):157-163. doi: 10.5152/dir.2021.20486.
We aimed to show the effects of long-term screening on clinical, pathologic, and survival outcomes in patients with screen-detected breast cancer and compare these findings with breast cancer patients registered in the National Breast Cancer Registry Data (NBCRD).
Women aged 40-69 years, living in Bahcesehir county, Istanbul, Turkey, were screened every 2 years using bilateral mammography. The Bahcesehir National Breast Cancer Registry Data (BMSP) data were collected during a 10-year screening period (five rounds of screening). BMSP data were compared with the NBCRD regarding age, cancer stage, types of surgery, tumor size, lymph node status, molecular subtypes, and survival rates.
During the 10-year screening period, 8758 women were screened with 22621 mammograms. Breast cancer was detected in 130 patients; 51 (39.2%) were aged 40-49 years. The comparison of breast cancer patients in the two programs revealed that BMSP patients had earlier stages, higher breast-conserving surgery rates, smaller tumor size, more frequent negative axillary nodal status, lower histologic grade, and higher ductal carcinoma in situ rates than NBCRD patients (p = 0.001, for all).
These results indicate the feasibility of successful population-based screening in middle-income countries.
本研究旨在展示长期筛查对筛查出的乳腺癌患者的临床、病理和生存结局的影响，并将这些发现与国家乳腺癌登记数据（NBCRD）中的乳腺癌患者进行比较。
土耳其伊斯坦布尔Bahcesehir 县年龄在 40-69 岁的女性每 2 年接受一次双侧乳房 X 线筛查。在为期 10 年的筛查期间（五轮筛查）收集了 Bahcesehir 国家乳腺癌登记数据（BMSP）。BMSP 数据与 NBCRD 的年龄、癌症分期、手术类型、肿瘤大小、淋巴结状态、分子亚型和生存率进行了比较。
在 10 年的筛查期间，8758 名女性接受了 22621 次乳房 X 线检查，共发现 130 例乳腺癌患者；其中 51 例（39.2%）年龄在 40-49 岁之间。对两个项目中的乳腺癌患者进行比较发现，BMSP 患者的分期更早、保乳手术率更高、肿瘤更小、腋窝淋巴结阴性率更高、组织学分级更低、导管原位癌比例更高（均为 p=0.001）。
这些结果表明，在中等收入国家开展基于人群的筛查是可行的。
