Max Planck Institute for Molecular Genetics, Otto-Warburg Laboratory, Ihnestrasse 63-73, D-14195 Berlin, Germany.
Nat Rev Microbiol. 2010 Jan;8(1):74-82. doi: 10.1038/nrmicro2243.
Mass spectrometry has become an important analytical tool in biology in the past two decades. In principle, mass spectrometry offers high-throughput, sensitive and specific analysis for many applications in microbiology, including clinical diagnostics and environmental research. Recently, several mass spectrometry methods for the classification and identification of bacteria and other microorganisms, as well as new software analysis tools, have been developed. In this Review we discuss the application range of these mass spectrometry procedures and their potential for successful transfer into microbiology laboratories.
质谱在过去二十年中已成为生物学中一种重要的分析工具。原则上，质谱为微生物学的许多应用提供高通量、灵敏和特异的分析，包括临床诊断和环境研究。最近，已经开发出几种用于细菌和其他微生物分类和鉴定的质谱方法以及新的软件分析工具。在这篇综述中，我们讨论了这些质谱程序的应用范围及其成功转化为微生物学实验室的潜力。
