Isaacs D, Dickson H, O'Callaghan C, Sheaves R, Winter A, Moxon E R
Departmetn of Paediatrics, John Radcliffe Hospital, Oxford.
Arch Dis Child. 1991 Feb;66(2):227-31. doi: 10.1136/adc.66.2.227.
Hospital acquired infections with respiratory syncytial virus are a major problem. The virus is spread predominantly by infected nasal secretions and we investigated whether we could reduce its incidence by cohorting babies on each ward into designated areas and encouraging staff and parents to wash their hands. We examined the incidence of hospital acquired infection due to respiratory syncytial virus in all children less than 2 years old and in those with congenital heart disease. In 1986-7, before any intervention, 18 (4.2%) of 425 hospitalised children less than 2 years old developed hospital acquired infection due to respiratory syncytial virus. In 1987-8, after intervention, five (0.6%) of 840 children developed hospital acquired infection but there were fewer ward admissions with community acquired infections due to the virus. In 1988-9, when there were more community acquired infections than 1986-7, six (1.1%) of 552 children developed hospital acquired infection. In 1986-7, eight (34.8%) of 23 children less than 2 years old with congenital heart disease developed hospital acquired infection due to respiratory syncytial virus; all eight were among 11 children with congenital heart disease hospitalised for more than 14 days. In 1987-8, one (3.3%) of 30 children with congenital heart disease developed hospital acquired infection due to respiratory syncytial virus and in 1988-9 there was one (2.1%) case out of 47 children with congenital heart disease. Handwashing and cohorting significantly reduce the incidence of nosocomial respiratory syncytial virus infection.
医院获得性呼吸道合胞病毒感染是一个主要问题。该病毒主要通过受感染的鼻腔分泌物传播，我们调查了是否可以通过将每个病房的婴儿分组到指定区域，并鼓励工作人员和家长洗手来降低其发病率。我们检查了所有2岁以下儿童以及患有先天性心脏病的儿童中因呼吸道合胞病毒导致的医院获得性感染的发生率。在1986 - 1987年，在任何干预措施实施之前，425名2岁以下住院儿童中有18名（4.2%）发生了因呼吸道合胞病毒导致的医院获得性感染。在1987 - 1988年，干预措施实施后，840名儿童中有5名（0.6%）发生了医院获得性感染，但因该病毒导致的社区获得性感染的病房入院人数减少了。在1988 - 1989年，当社区获得性感染比1986 - 1987年更多时，552名儿童中有6名（1.1%）发生了医院获得性感染。在1986 - 1987年，23名2岁以下患有先天性心脏病的儿童中有8名（34.8%）发生了因呼吸道合胞病毒导致的医院获得性感染；这8名儿童均在11名住院超过14天的先天性心脏病儿童之中。在1987 - 1988年，30名患有先天性心脏病的儿童中有1名（3.3%）发生了因呼吸道合胞病毒导致的医院获得性感染，在1988 - 1989年，47名患有先天性心脏病的儿童中有1名（2.1%）发生了感染。洗手和分组显著降低了医院获得性呼吸道合胞病毒感染的发生率。
