2nd Department of Pediatrics, Aristotle University of Thessaloniki, School of Medicine, Ahepa General Hospital, St. Kiriakidi 1, 54636 Thessaloniki, Greece.
Int J Endocrinol. 2010;2010:472173. doi: 10.1155/2010/472173.
Vitamin D deficiency is common in the developing countries and exists in both childhood and adult life. The great importance of Vitamin D is the moderation of calcium (Ca) and phosphorus (P) homeostasis as well as the absorption of Ca. While insufficiency of vitamin D is a significant contributing factor to risk of rickets in childhood, it is possible that a more marginal deficiency of vitamin D during life span contribute to osteoporosis as well as potentially to the development and various other chronic diseases such as cardiovascular disease, cancer and diabetes. This paper reviews the metabolism, epidemiology, and treatment of vitamin D and calcium insufficiency as well as its relation to various diseases during childhood and adolescence.
维生素 D 缺乏在发展中国家很常见,存在于儿童期和成年期。维生素 D 的重要性在于调节钙(Ca)和磷(P)的体内平衡以及钙的吸收。虽然维生素 D 不足是导致儿童佝偻病的一个重要因素,但在整个生命周期中,维生素 D 更轻微的缺乏可能会导致骨质疏松症,以及潜在的心血管疾病、癌症和糖尿病等各种慢性疾病的发展。本文综述了维生素 D 和钙不足的代谢、流行病学和治疗及其与儿童和青少年时期各种疾病的关系。