溃疡性结肠炎的医学治疗。
Medical treatment of ulcerative colitis.
作者信息
Mahadevan Uma
机构信息
Division of Gastroenterology, University of California, San Francisco, CA 94115, USA.
出版信息
Clin Colon Rectal Surg. 2004 Feb;17(1):7-19. doi: 10.1055/s-2004-823066.
Abstract
Ulcerative colitis is a chronic inflammatory disease of the colon with an increasing incidence worldwide. The medical management of this disease continues to expand as drugs to induce and maintain remission are sought to avoid the need for colectomy. This article will review the standard of care for the treatment of mild, moderate, and severe ulcerative colitis. The efficacy, optimal usage, and adverse events profile of agents such as 5-aminosalicylates, corticosteroids, azathioprine, and cyclosporine will be discussed and an algorithm for their use will be developed. Alternative and experimental therapies such as monoclonal antibodies, probiotics, and heparin will also be addressed.
摘要
溃疡性结肠炎是一种结肠的慢性炎症性疾病，在全球范围内发病率呈上升趋势。随着人们寻求诱导和维持缓解的药物以避免结肠切除术，该疾病的药物治疗不断扩展。本文将综述轻度、中度和重度溃疡性结肠炎的治疗标准。将讨论5-氨基水杨酸类药物、皮质类固醇、硫唑嘌呤和环孢素等药物的疗效、最佳用法及不良事件概况，并制定其使用算法。还将探讨单克隆抗体、益生菌和肝素等替代疗法及实验性疗法。
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